HSPD1 Protein (partial)
(2 references)Quick Overview for HSPD1 Protein (partial) (ABIN1686691)
抗原
See all HSPD1 蛋白蛋白类型
宿主
资源
应用范围
纯度
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产品特性
- partial
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序列
- EDPYEKIGAE LVKEVAKKTD DVAGDGTTTA TVLAQALVRE GLRNVAAGAN PLGLKRGIEK AVEKVTETLL KGAKEVETKE QIAATAAISA GDQSIGDLIA EAMDKVGNEG VITVEESNTF GLQLELTEGM RFDKGYISGY FVTDPERQEA VLEDPYILLV SSKVSTVKDL LPLXXXXXXX GKPLLIIAED VEGEALSTLV
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特异性
- ~65 kDa
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纯化方法
- Multi-Step Purified
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Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) (AA 225-573) protein (GST tag)
HSPD1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) (AA 225-573) protein (His-IF2DI Tag)HSPD1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) (AA 1-573) protein (GST tag)HSPD1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) (AA 27-573) protein (His tag)HSPD1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90% by SDS-PAGE SDS
Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) protein (His tag)HSPD1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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This product has been certified >90% pure using SDS-PAGE analysis.
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限制
- 仅限研究用
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浓度
- Lot specific
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缓冲液
- 10 mM Tris pH 8, 105 mM NaCl, 5 mM EDTA
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储存条件
- -20 °C
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: "Heat shock protein 65 promotes atherosclerosis through impairing the properties of high density lipoprotein." in: Atherosclerosis, Vol. 237, Issue 2, pp. 853-61, (2014) (PubMed).
: "Detection of autoantibodies against heat shock proteins and collapsin response mediator proteins in autoimmune retinopathy." in: BMC ophthalmology, Vol. 13, pp. 48, (2013) (PubMed).
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: "Heat shock protein 65 promotes atherosclerosis through impairing the properties of high density lipoprotein." in: Atherosclerosis, Vol. 237, Issue 2, pp. 853-61, (2014) (PubMed).
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- HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))
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背景
- HSP65 isolated from Mycobacterium bovis BCG, is a member of the HSP60 family of heat shock proteins (2, 3). HSP60s are mitochondrial chaperonins that are typically held responsible for the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. In addition to its role as a heat shock protein, HSP60 functions as a chaperonin to assist in folding linear amino acid chains into their respective three-dimensional structure. HSP60s are a ubiquitous class of HSPs that specifically promote the folding and assembly of cellular polypeptides in an ATP-dependent manner (1). Specifically, sequence comparison of HSP65 from different mycobacterium strains showed that the protein sequence of M. bovis BCG is identical to that of M. tuberculosis, and very similar to that of M. leprae, the pathogens that cause tuberculosis and tuberculoid leprosy, respectively (2,4). Mycobacterium bovis BCG HSP65 was identified as the immunodominant antigen during mycobacterial diseases and vaccination. It is also believed to be the antigen that induces autoimmune disease, such as adjuvant arthritis in rats (5, 6).
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分子量
- approx. 65 kDa
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UniProt
- Q1EHB9
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途径
- Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
抗原
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