IL-17 蛋白
IL17
宿主: 小鼠
宿主: 大肠杆菌（E. Coli）
> 95 %, as determined by SDS-PAGE and HPLC
Active
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- 抗原 See all IL-17 (IL17) 蛋白
- IL-17 (IL17) (Interleukin 17 (IL17))
- 生物活性
- Active
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宿主
- 小鼠
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资源
- 大肠杆菌（E. Coli）
- 特异性
- Optimized DNA sequence encoding Mouse Interleukin-17A mature chain was expressed in Escherichia Coli.
- 产品特性
- Native Mouse Interleukin17A, generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 16kDa. Recombinant Mouse IL-17A is a disulfide-linked monodimeric protein consisting of 137 amino acid residue subunits, and migrates as an approximately 16kDa protein under reducing conditions in SDS-PAGE.
- 纯度
- > 95 %, as determined by SDS-PAGE and HPLC
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
- Top Product
- Discover our top product IL17 蛋白
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- 说明
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The activity was measured by the ability to bind Human IL17RA in a functional ELISA assay with a linear range of 10-500 ng/mL. Complete precursor sequence shown, expressed chain highlighted
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
- 缓冲液
- PBS solution pH 7.5.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- The lyophilized protein is stable for at least years from date of receipt at -20 °C. Upon reconstitution, this cytokine can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months, with a carrier protein without detectable loss of activity.
- 有效期
- 12-24 months
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- 抗原
- IL-17 (IL17) (Interleukin 17 (IL17))
- 别名
- IL-17 (IL17 产品)
- 别名
- CTLA8 Protein, IL-17 Protein, IL-17A Protein, IL17 Protein, Ctla-8 Protein, Ctla8 Protein, Il17 Protein, ChIL-17 Protein, IL-17F Protein, IL17A Protein, CTLA-8 Protein, interleukin 17A Protein, IL17A Protein, Il17a Protein
- 背景
- IL-33, a member of the IL-1 family, signals via a heterodimeric receptor complex consisting of ST2 and IL-1R accessory protein and triggers the activation of NF-B and all three MAPKs: p38, ERK1/2, and JNK1/2 in mast cells. IL-33 is expressed in multiple tissues and by several cell types such as dermal fibroblasts and small airway epithelial and bronchial smooth muscle cells. IL-33 activated IL-1-like signaling responses in mast cells and enhanced IL-5 and IL-13 production from murine Th2-polarized splenocytes.Moreover, it was found that both human and murine mast cells when stimulated in vitro with IL-33 produced a wide spectrum of cytokines and chemokines. In addition, IL-33 enhanced IL-4-driven Th2 cell responses and acted as a selective chemoattractant for Th2 cell recruitment.
- UniProt
- Q62386
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