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Podoplanin Protein (PDPN) (Soluble) (His tag)

This anti-Podoplanin antibody (ABIN1589762) is a Escherichia coli (E. coli) antibody detecting Podoplanin in . Suitable for Mouse.
产品编号 ABIN1589762
发货至: 中国

Quick Overview for Podoplanin Protein (PDPN) (Soluble) (His tag) (ABIN1589762)

抗原

See all Podoplanin (PDPN) 蛋白
Podoplanin (PDPN)

蛋白类型

Recombinant

宿主

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小鼠

资源

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大肠杆菌(E. Coli)

纯度

> 95 % by SDS-PAGE
  • 产品特性

    Soluble

    标记

    This Podoplanin protein is labelled with His tag.

    原理

    Podoplanin, soluble

    序列

    GTIGVNEDDI VTPGTGDGMV PPGIEDKITT TGATGGLNES TGKAPLVPTQ RERGTKPPLE ELSTSATSDH DHREHESTTT VKVVTSHSVD KKTSHPNRDN AGDETQTTDK KDGLPVVTLE HHHHHH

    特异性

    Chromosomal location:4 E1, 4

    产品特性

    Length (aa):126
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  • 说明

    Soluble Receptors

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    We recommend a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use.

    缓冲液

    PBS

    注意事项

    Centrifuge vial prior to opening.

    储存条件

    RT,-20 °C

    储存方法

    The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted sPodoplanin should be stored in working aliquots at -20°C.
  • 抗原

    Podoplanin (PDPN)

    别名

    Podoplanin

    背景

    Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46 % aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Through its association with CLEC2, Podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.
    Synonyms: Pdpn, T1a, Gp38, OTS-8, T1alpha, RANDAM-2, T1-alpha

    基因ID

    14726

    NCBI登录号

    NM_010329, NP_034459

    UniProt

    Q62011

    途径

    Dicarboxylic Acid Transport
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