MESP1 蛋白
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- 抗原 See all MESP1 蛋白
- MESP1 (Mesoderm Posterior 1 (MESP1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Insect Cells
- 序列
- MAQPLCPPLS ESWMLSAAWG PTRRPPPSDK DCGRSLVSSP DSWGSTPADS PVASPARPGT LRDPRAPSVG RRGARSSRLG SGQRQSASER EKLRMRTLAR ALHELRRFLP PSVAPAGQSL TKIETLRLAI RYIGHLSAVL GLSEESLQRR CRQRGDAGSP RGCPLCPDDC PAQMQTRTQA EGQGQGRGLG LVSAVRAGAS WGSPPACPGA RAAPEPRDPP ALFAEAACPE GQAMEPSPPS PLLPGDVLAL LETWMPLSPL EWLPEEPK
- 产品特性
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Length (AA): 268
Chromosomal location: 15q26.1 - 纯度
- > 95 % by SDS-PAGE. Visualized by silver stain
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- Discover our top product MESP1 蛋白
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Mesoderm Posterior 1 (MESP1) (AA 1-63) protein (GST tag)
MESP1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Mesoderm Posterior 1 (MESP1) (AA 1-268) protein (Strep Tag)Crystallography grade MESP1 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Mesoderm Posterior 1 (MESP1) (AA 1-243) protein (Strep Tag)Crystallography grade MESP1 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Mesoderm Posterior 1 (MESP1) protein (Myc-DYKDDDDK Tag)MESP1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Not determined yet.
- 说明
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Cytokines & Growth Factors
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Human MesP1 should be reconstituted in sterile water to a concentration of 0.1 mg/mL. This solution can be diluted in water or other buffer solutions or stored at -20 °C.
- 缓冲液
- 0.5X PBS
- 注意事项
- Freeze/thaw cycles will result in significant loss of activity.
- 储存条件
- 0 °C
- 储存方法
- The lyophilized human MesP1, though stable at room temperature, is best stored desiccated below 0 °C.
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- 抗原
- MESP1 (Mesoderm Posterior 1 (MESP1))
- 别名
- MesP1 (MESP1 产品)
- 别名
- bHLHc5 Protein, mesp Protein, mesp1 Protein, mespa Protein, CMESO-1 Protein, CMESO2 Protein, MESP1 Protein, mesoderm posterior 1 Protein, mesoderm posterior bHLH transcription factor 1 Protein, mesoderm posterior 1 homolog (mouse) Protein, mesoderm posterior homolog B Protein, mesoderm posterior homolog B L homeolog Protein, Mesp1 Protein, MESP1 Protein, mesp1 Protein, mespb Protein, mespb.L Protein
- 背景
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ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1 (1,2). As one of the earliest markers, it is expressed specifically in almost all cardiovascular precursors and is required for cardiac morphogenesis (2,3). It was shown that MesP1 is a key factor sufficient to induce the formation of ectopic heart tissue in vertebrates and increase cardiovasculogenesis by ES cells. Electrophysiological analysis showed all subtypes of cardiac ES-cell differentiation (4). MesP1 overexpression and knockdown experiments revealed a prominent function of MesP1 in a gene regulatory cascade, causing Dkk-1-mediated blockade of canonical Wnt-signalling. Independent evidence from ChIP and in vitro DNA-binding studies, expression analysis in wild-type and MesP knockout mice, and reporter assays confirm that Dkk-1 is a direct target of MesP1.
Synonyms: MESP1, bHLHc5 - 分子量
- 34 kDa
- NCBI登录号
- NM_018670, NP_061140
- UniProt
- Q9BRJ9
- 途径
- Regulation of Muscle Cell Differentiation
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