GREM1 蛋白
Quick Overview for GREM1 蛋白 (ABIN1589733)
抗原
See all GREM1 蛋白蛋白类型
宿主
资源
纯度
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原理
- Gremlin-1
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序列
- MKKKGSQGAI PPPDKAQHND SEQTQSPPQP GSRTRGRGQG RGTAMPGEEV LESSQEALHV TERKYLKRDW CKTQPLKQTI HEEGCNSRTI INRFCYGQCN SFYIPRHIRK EEGSFQSCSF CKPKKFTTMM VTLNCPELQP PTKKKRVTRV KQCRCISIDL D
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特异性
- Chromosomal location:2 E4, 2 64.5 cM
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产品特性
- Length (aa):161
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Gremlin 1 (GREM1) (Active) protein
GREM1 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） WB, SDS Active
Gremlin 1 (GREM1) (AA 25-184) (Active) protein (Fc Tag)GREM1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Gremlin 1 (GREM1) (AA 25-184) protein (His-IF2DI Tag)GREM1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Gremlin 1 (GREM1) (AA 25-124) protein (GST tag)GREM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Gremlin 1 (GREM1) (AA 1-184) protein (GST tag)GREM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Gremlin 1 (GREM1) (AA 25-184) (Active) protein (His tag)GREM1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
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说明
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Cytokines & Growth Factors
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Mouse Grem-1 should be reconstituted in 50 mM acetic acid or water to a concentration of 0.1 mg/mL. This solution can be diluted in water or other buffer solutions or stored at -20 °C.
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缓冲液
- 50 mM acetic acid
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储存条件
- RT,0 °C
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储存方法
- The lyophilized mouse Grem-1, though stable at room temperature, is best stored desiccated below 0°C
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- GREM1 (Gremlin 1 (GREM1))
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别名
- Gremlin-1
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背景
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Gremlin was identified in a Xenopus expression cloning screen as a dorsalizing factor that can induce a secondary axis. A rat homolog, called Drm, was identified as a cDNA that was down regulated in v Mos transfected cells. Gremlin/Drm belongs to the DAN family of secreted glycoproteins that are BMP antagonists. Other members of the family include: Cerberus, Dante, PRDC, Caronte and DAN. DAN family members share a cysteine-rich domain that is structurally related to the cysteine-knot motif found in TGFβ superfamily ligands. In vitro, Gremlin/Drm binds BMP4 and BMP2 indicating that it might interfere with BMP signaling. Gremlin/Drm acts as a BMP2/ 4 antagonist in a variety of tissues and developmental processes including: Xenopus animal cap explants, chick limb bud outgrowth and chondrogenesis, murine lung branching morphogenesis, and osteogenic differentiation of mouse myoblasts and bone marrow stromal cells. In addition, expression of Gremlin/Drm has been shown to be down-regulated in a wide range of human cancer cell lines. Mouse, human, chick and Xenopus homologs of Gremlin share over 80 % amino acid identity. It is likely that various DAN family members and other BMP antagonists including Noggin, Chordin, Follistatin and TSG can selectively antagonize the activities of different subsets of TGFβ superfamily ligands.
Synonyms: Grem1, ld, Drm, Cktsf1b1 -
分子量
- 20.7 kDa
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基因ID
- 23892
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NCBI登录号
- NM_011824, NP_035954
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UniProt
- O70326
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途径
- Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location
抗原
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