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GREM1 蛋白

This Recombinant GREM1 protein is expressed in 大肠杆菌(E. Coli).
产品编号 ABIN1589733
发货至: 中国

Quick Overview for GREM1 蛋白 (ABIN1589733)

抗原

See all GREM1 蛋白
GREM1 (Gremlin 1 (GREM1))

蛋白类型

Recombinant

宿主

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小鼠

资源

  • 12
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  • 1
大肠杆菌(E. Coli)

纯度

> 95 % by SDS-PAGE
  • 原理

    Gremlin-1

    序列

    MKKKGSQGAI PPPDKAQHND SEQTQSPPQP GSRTRGRGQG RGTAMPGEEV LESSQEALHV TERKYLKRDW CKTQPLKQTI HEEGCNSRTI INRFCYGQCN SFYIPRHIRK EEGSFQSCSF CKPKKFTTMM VTLNCPELQP PTKKKRVTRV KQCRCISIDL D

    特异性

    Chromosomal location:2 E4, 2 64.5 cM

    产品特性

    Length (aa):161
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  • 说明

    Cytokines & Growth Factors

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Mouse Grem-1 should be reconstituted in 50 mM acetic acid or water to a concentration of 0.1 mg/mL. This solution can be diluted in water or other buffer solutions or stored at -20 °C.

    缓冲液

    50 mM acetic acid

    储存条件

    RT,0 °C

    储存方法

    The lyophilized mouse Grem-1, though stable at room temperature, is best stored desiccated below 0°C
  • 抗原

    GREM1 (Gremlin 1 (GREM1))

    别名

    Gremlin-1

    背景

    Gremlin was identified in a Xenopus expression cloning screen as a dorsalizing factor that can induce a secondary axis. A rat homolog, called Drm, was identified as a cDNA that was down regulated in v Mos transfected cells. Gremlin/Drm belongs to the DAN family of secreted glycoproteins that are BMP antagonists. Other members of the family include: Cerberus, Dante, PRDC, Caronte and DAN. DAN family members share a cysteine-rich domain that is structurally related to the cysteine-knot motif found in TGFβ superfamily ligands. In vitro, Gremlin/Drm binds BMP4 and BMP2 indicating that it might interfere with BMP signaling. Gremlin/Drm acts as a BMP2/ 4 antagonist in a variety of tissues and developmental processes including: Xenopus animal cap explants, chick limb bud outgrowth and chondrogenesis, murine lung branching morphogenesis, and osteogenic differentiation of mouse myoblasts and bone marrow stromal cells. In addition, expression of Gremlin/Drm has been shown to be down-regulated in a wide range of human cancer cell lines. Mouse, human, chick and Xenopus homologs of Gremlin share over 80 % amino acid identity. It is likely that various DAN family members and other BMP antagonists including Noggin, Chordin, Follistatin and TSG can selectively antagonize the activities of different subsets of TGFβ superfamily ligands.
    Synonyms: Grem1, ld, Drm, Cktsf1b1

    分子量

    20.7 kDa

    基因ID

    23892

    NCBI登录号

    NM_011824, NP_035954

    UniProt

    O70326

    途径

    Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location
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