PDGF-AB Heterodimer (Homodimer) (Active) 蛋白
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北京 101111
Quick Overview for PDGF-AB Heterodimer (Homodimer) (Active) 蛋白 (ABIN1589627)
抗原
蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- Homodimer
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原理
- Recombinant Human PDGF-AB Protein
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序列
- Alpha chain: SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPT Beta chain: SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT
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特异性
- Chromosomal location:7p22/22q13.1
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产品特性
- Length (aa):126/110
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内毒素水平
- < 0.1 ng per ug of PDGF-AB
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应用备注
- The biological activity was determined by the induction of proliferation in NHDF cells (Normal Human Dermal Fibroblasts).
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说明
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Cytokines & Growth Factors
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 50 mM acetic acid,Centrifuge vial prior to opening. The lyophilized PDGF-AB should be reconstituted in 50 mM acetic acid to a concentration not lower than 100 μg/mL. For long term storage of reconstituted protein addition of carrier protein (e.g. BSA or HSA, 0.1 % ) is recommended.
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缓冲液
- 50 mM acetic acid
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注意事项
- Avoid repeated freeze-thaw cycles. Centrifuge vial prior to opening
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储存条件
- -20 °C,-80 °C
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储存方法
- The lyophilized PDGF-AB is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted PDGF-AB is best stored at -20°C to -70°C. Avoid repeated freeze-thaw cycles.
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有效期
- 2-3 weeks
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- PDGF-AB Heterodimer
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别名
- PDGF-AB
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背景
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Synonyms: PDGFA, PDGF1, PDGF-A
Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AB is a 25.5 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).
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分子量
- 25.5 kDa
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基因ID
- 5154, 5155
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NCBI登录号
- NM_002608, NM_002607, NP_002599, NP_002598
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UniProt
- P04085
抗原
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