BMP2 Protein (Homodimer)
(5 references)Quick Overview for BMP2 Protein (Homodimer) (ABIN1589575)
抗原
See all BMP2 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- Homodimer
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序列
- MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
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产品特性
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Length (AA): 115
Chromosomal location: 20p12
Measured by the ability of BMP-2 to induce alkaline phosphatase production by C2C12 myogenic cells. The ED50 for this effect is typically 0.3-0.8 µg/mL. -
内毒素水平
- < 0.1 ng per mg of BMP-2
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Bone Morphogenetic Protein 2 (BMP2) (AA 283-396) (Active) protein
BMP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as analyzed by non-reducing SDS-PAGE. Active
Bone Morphogenetic Protein 2 (BMP2) (AA 283-396) proteinBMP2 宿主: 人, 犬, 小鼠, 大鼠, 猕猴 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE
Bone Morphogenetic Protein 2 (BMP2) (AA 231-330) protein (GST tag)BMP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Bone Morphogenetic Protein 2 (BMP2) (AA 283-396) protein (GST tag)BMP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Bone Morphogenetic Protein 2 (BMP2) (AA 1-396) protein (GST tag)BMP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Bone Morphogenetic Protein 2 (BMP2) (AA 283-396) protein (Fc Tag)BMP2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Bone Morphogenetic Protein 2 (BMP2) (AA 284-396) proteinBMP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >92 % as determined by SDS-PAGE.
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说明
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Cytokines & Growth Factors
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- The lyophilized BMP-2 is best soluble in 50 mM acetic acid at a concentration of 0.1 mg/mL but should be also soluble in most aqueous buffers when the pH is below 6.0.
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缓冲液
- 50 mM acetic acid
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C/-80 °C
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储存方法
- Lyophilized samples are stable for greater than six months at -20 °C to -70 °C. Reconstituted BMP-2 should be stored in working aliquots at -20 °C.
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有效期
- 6 months
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: "Hollow hydroxyapatite microspheres/chitosan composite as a sustained delivery vehicle for rhBMP-2 in the treatment of bone defects." in: Journal of materials science. Materials in medicine, Vol. 26, Issue 1, pp. 5336, (2015) (PubMed).
: "Functionalization of titanium implants using a modular system for binding and release of VEGF enhances bone-implant contact in a rodent model." in: Journal of clinical periodontology, Vol. 42, Issue 3, pp. 302-10, (2015) (PubMed).
: "Osteogenic differentiation and proliferation of bone marrow-derived mesenchymal stromal cells on PDLLA?+?BMP-2-coated titanium alloy surfaces." in: Journal of biomedical materials research. Part A, (2015) (PubMed).
: "Release and bioactivity of bone morphogenetic protein-2 are affected by scaffold binding techniques in vitro and in vivo." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 197, pp. 148-57, (2014) (PubMed).
: "Improved anchorage of Ti6Al4V orthopaedic bone implants through oligonucleotide mediated immobilization of BMP-2 in osteoporotic rats." in: PLoS ONE, Vol. 9, Issue 1, pp. e86151, (2014) (PubMed).
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: "Hollow hydroxyapatite microspheres/chitosan composite as a sustained delivery vehicle for rhBMP-2 in the treatment of bone defects." in: Journal of materials science. Materials in medicine, Vol. 26, Issue 1, pp. 5336, (2015) (PubMed).
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- BMP2 (Bone Morphogenetic Protein 2 (BMP2))
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别名
- BMP-2
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背景
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Human Bone Morphogenetic Protein-2 (BMP-2) is a disulfide-bonded homodimeric protein with an apparent molecular weight of 26 kDa. BMP-2 regulates similarly to its nearest homologue BMP-4 diverse fundamental processes during embryonic development: BMP-2 and other BMP proteins have great potential for medical therapeutic applications, in particular because they allow or at least accelerate the ossification of extensive bone lesions. The amino acid sequence of recombinant human BMP-2 starts with MQAKHKQ (position 283) containing the Met from the E. coli expression vector. BMP-2 is a heparin binding protein.
Synonyms: bone morphogenetic protein 2, BDA2, BMP2A, bone morphogenetic protein 4, ZYME, BMP2B, OFC11, BMP2B1, MCOPS6 -
分子量
- 26.0 kDa
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NCBI登录号
- NM_001200, NP_001191
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UniProt
- P12643
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途径
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Growth Factor Binding, Positive Regulation of fat Cell Differentiation
抗原
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