CDNF 蛋白
This Recombinant CDNF protein is expressed in CHO Cells.
产品编号 ABIN1405917
发货至:
中国
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Quick Overview for CDNF 蛋白 (ABIN1405917)
抗原
See all CDNF 蛋白
CDNF
(Cerebral Dopamine Neurotrophic Factor (CDNF))
蛋白类型
Recombinant
生物活性
Active
宿主
人
资源
CHO Cells
应用范围
Western Blotting (WB), SDS-PAGE (SDS), Cell Culture (CC), In vivo Studies (in vivo)
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产品特性
- Biological properties: Protein is biologically active. Suitable for cell culture and in vivo testing. Biological activity of human CDNF was tested in rat 6-OHDA model of Parkinson’s disease and shown to be both neuroprotective and neurorestorative (for methods see: Lindholm et al. 2007, Voutilainen et al. 2011)
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纯化方法
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Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media.
Protein is sterile-filtrated through 0.22 µg filter.
Purified human CDNF is characterized as homogenous material by mass-spectroscopy. -
内毒素水平
- Less than 1EU/µg of protein as determined by LAL method
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Cerebral Dopamine Neurotrophic Factor (CDNF) (AA 25-187) protein (His-IF2DI Tag)
CDNF 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Cerebral Dopamine Neurotrophic Factor (CDNF) protein (His tag)CDNF 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
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说明
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Synonyms: Cerebral dopamine neurotrophic factor - CDNF, ARMETL1.
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限制
- 仅限研究用
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浓度
- 1 mg/ml Concentration of the protein is determined by BCA Protein Analysis kit (Pierce). BSA was used as a standard
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缓冲液
- PBS pH 7.5
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注意事项
- Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles.
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储存条件
- -80 °C
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- CDNF (Cerebral Dopamine Neurotrophic Factor (CDNF))
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别名
- CDNF
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背景
- CDNF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007, Voutilainen et al., 2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine neurons in rodent models of Parkinson’s disease. When administered after 6-OHDA or MPTP –lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta.
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分子量
- Approximately 18.5 kDa, a single non-glycosylated polypeptide chain containing 163 amino acids.
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UniProt
- Q49AH0
抗原
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