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Quick Overview for FIL1d 蛋白 (ABIN1343995)
抗原
See all FIL1d 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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原理
- IL-36Ra (aa 3-156) (mouse) (rec.) (untagged)
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交叉反应
- 小鼠
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产品特性
- Mouse IL36Ra (aa Val3-Asp156) is untagged.
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内毒素水平
- <0.05EU/μg purified protein (LAL test).
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Biological Activity Comment
- Inhibits the IL-6 induced expression of IL-36alpha (IL-1F6), IL-36beta (IL-1F8), and IL-36gamma (IL-1F9) in BMDCs. 1μg/ml of IL-36Ra inhibits the activity of 10 ng to 100 ng/ml of the agonists.
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Interleukin 1 delta (FIL1d) (Active) protein
FIL1d 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Interleukin 1 delta (FIL1d) (AA 1-155) protein (His tag)FIL1d 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 1 delta (FIL1d) (Transcript Variant 2) (Active) proteinFIL1d 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, STD, PI Active
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute with 100 μL sterile water.
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浓度
- 0.1 mg/mL
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缓冲液
- Contains PBS.
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注意事项
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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有效期
- 6 months
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- FIL1d (Interleukin 1 delta (FIL1d))
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别名
- IL-36Ra
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背景
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Interleukin-36 Receptor Antagonist Protein, IL-1F5, Interleukin-1 Family Member 5, IL-1delta, Interleukin-1delta, Interleukin-1 Homolog 3, Interleukin-1-like Protein 1
IL-36Ra/IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are target of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
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分子量
- ~17kDa
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UniProt
- Q9QYY1
抗原
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