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beta-2 Microglobulin 蛋白

Name: beta-2 Microglobulin 蛋白
SKU: ABIN1305114
Availability: OutOfStock

B2M 宿主: 人宿主: Insect Cells Recombinant Func

(2 references)

产品编号 ABIN1305114

发货至: 中国

Datasheet as PDF

抗原 See all beta-2 Microglobulin (B2M) 蛋白

beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

蛋白类型

Recombinant
宿主
12

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3

2

1

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1
人
资源
48

11

10

1

1

1

1
Insect Cells

应用范围

Functional Studies (Func)

品牌

BD Pharmingen™

纯化方法

Human β2 Microglobulin recombinant protein was expressed in insect cells. The expressed protein was purified by a combination of ion-exchange and gel-filtration methods.

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beta-2-Microglobulin (B2M) (AA 21-119) protein (His tag)
B2M 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

beta-2-Microglobulin (B2M) (AA 21-119) protein (His tag)
B2M 宿主: 猕猴, Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

beta-2-Microglobulin (B2M) (AA 21-119) protein (Fc Tag)
B2M 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

beta-2-Microglobulin (B2M) (AA 21-119) protein (Fc Tag)
B2M 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

beta-2-Microglobulin (B2M) (AA 1-119) protein (GST tag)
B2M 宿主: 人宿主: 小麦胚 Recombinant ELISA, WB, AP, AA

beta-2-Microglobulin (B2M) (AA 21-119) protein (His tag)
Crystallography grade B2M 宿主: 小鼠宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB, Crys

beta-2-Microglobulin (B2M) (AA 21-119) protein (His tag)
B2M 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant >90 % as determined by reducing SDS-PAGE.

beta-2-Microglobulin (B2M) (AA 21-119) protein (His tag)
B2M 宿主: 大鼠宿主: 大肠杆菌（E. Coli） Recombinant >90 % as determined by reducing SDS-PAGE.

beta-2-Microglobulin (B2M) (AA 21-119) protein (His tag)
B2M 宿主: 小鼠宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by reducing SDS-PAGE.

beta-2-Microglobulin (B2M) (AA 1-119) protein (His tag)
B2M 宿主: 小鼠宿主: HEK-293 Cells Recombinant >95 % as determined by reducing SDS-PAGE.

说明

BD Pharmingen™ Recombinant Human β2 Microglobulin

限制

仅限研究用
状态

Liquid

浓度

0.5 mg/mL

缓冲液

Aqueous buffered solution containing ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

The major histocompatibility complex (MHC) gene locus encodes a group of highly polymorphic, cell surface proteins that play a broad role in the immune response to protein antigens. MHC molecules function by binding and presenting small antigenic protein fragments to antigen-specific receptors expressed by T cells (TCR). Class I MHC molecules consist of two separate polypeptide chains. The class I α chain is an MHC encoded, transmembrane polypeptide containing three extracellular domains: α1, α2 and α3. The second chain consists of a non-MHC encoded, 12 kD polypeptide called β2 microglobulin (β2M). Since β2M does not contain a transmembrane domain, it associates with the a chain through non-covalent interaction. This association is important for the stability of the MHC class I structure, its peptide-loading and its ability to present peptide antigen to CD8+ T cells. β2M is relatively invariant within each species. For example, human β2M is reported to have high affinity for human and mouse MHC class I heavy chains.

储存条件

4 °C

储存方法

Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.
Shields, Moffat, Ribaudo: "Functional comparison of bovine, murine, and human beta2-microglobulin: interactions with murine MHC I molecules." in: Molecular immunology, Vol. 35, Issue 14-15, pp. 919-28, (1999) (PubMed).

Silver, Parker, Wiley: "Reconstitution by MHC-restricted peptides of HLA-A2 heavy chain with beta 2-microglobulin, in vitro." in: Nature, Vol. 350, Issue 6319, pp. 619-22, (1991) (PubMed).
抗原

beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

别名

beta 2 microglobulin (B2M 产品)

别名

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背景

The major histocompatibility complex (MHC) gene locus encodes a group of highly polymorphic, cell surface proteins that play a broad role in the immune response to protein antigens. MHC molecules function by binding and presenting small antigenic protein fragments to antigen-specific receptors expressed by T cells (TCR). Class I MHC molecules consist of two separate polypeptide chains. The class I α chain is an MHC encoded, transmembrane polypeptide containing three extracellular domains: α1, α2 and α3. The second chain consists of a non-MHC encoded, 12 kD polypeptide called β2 microglobulin (β2M). Since β2M does not contain a transmembrane domain, it associates with the a chain through non-covalent interaction. This association is important for the stability of the MHC class I structure, its peptide-loading and its ability to present peptide antigen to CD8+ T cells. β2M is relatively invariant within each species. For example, human β2M is reported to have high affinity for human and mouse MHC class I heavy chains.

途径

TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process