CXCL2 Protein (AA 39-107)
Quick Overview for CXCL2 Protein (AA 39-107) (ABIN1096467)
抗原
See all CXCL2 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 39-107
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原理
- Recombinant Human C-X-C Motif Chemokine 2/CXCL2
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序列
- MTELRCQCLQ TLQGIHLKNI QSVKVKSPGP HCAQTEVIAT LKNGQKACLN PASPMVKKII EKMLKNGKSN
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产品特性
- Recombinant Human C-X-C Motif Chemokine 2/CXCL2 is produced with our E. coli expression system. The target protein is expressed with sequence (Thr39-Asn107) of Human CXCL2.
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过滤
- 0.2 μm filtered
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内毒素水平
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
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Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (Active) protein
CXCL2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (Active) proteinCXCL2 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (Active) proteinCXCL2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (AA 1-107) protein (GST tag)CXCL2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (AA 35-107) protein (His tag)CXCL2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (AA 32-100) protein (His tag)CXCL2 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (AA 28-100) protein (His tag)CXCL2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) proteinCXCL2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (AA 35-107) protein (His-DYKDDDDK-Strep II Tag)CXCL2 宿主: 人 宿主: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Chemokine (C-X-C Motif) Ligand 2 (CXCL2) (AA 28-100) protein (His tag)CXCL2 宿主: 小鼠 宿主: Yeast (Pichia pastoris) Recombinant > 95 % SDS, WB, ELISA, IP
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. -
缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM TrisHCl, 400 mM NaCl, pH 8.5.
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注意事项
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
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储存条件
- 4 °C/-20 °C/-80 °C
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储存方法
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. -
有效期
- 3 months
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- CXCL2 (Chemokine (C-X-C Motif) Ligand 2 (CXCL2))
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别名
- mip-2
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背景
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Chemokine (C-X-C Motif) Ligand 2 (CXCL2) is a small secreted cytokine which belongs to the CXC chemokine family. CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. CXCL2/MIP2-alpha is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2. CXCL2/MIP2-alpha has been known to regulate immune functions mainly by chemo-attracting neutrophils. It is produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is a hematoregulatory chemokine, which suppresses hematopoietic progenitor cell proliferation. CXCL2 can be induced by receptor activator of NF-kappaB ligand, the osteoclast (OC) differentiation factor, through JNK and NF-kappaB signaling pathways in OC precursor cells. CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-derived macrophages (BMMs) through the activation of ERK. Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs. During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs. CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.
Alternative Names: C-X-C Motif Chemokine 2, Growth-Regulated Protein Beta, Gro-Beta, Macrophage Inflammatory Protein 2-Alpha, MIP2-Alpha, CXCL2, GRO2, GROB, MIP2A, SCYB2 -
分子量
- 7.67 kDa
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UniProt
- P19875
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途径
- Cellular Response to Molecule of Bacterial Origin
抗原
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