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Lipocalin 2 Protein (LCN2) (full length)

LCN2 宿主: 人 宿主: Human Native > 95 %(SDS-PAGE) WB, SDS, ELISA, LETIA
产品编号 ABIN1045129
发货至: 中国
  • 抗原 See all Lipocalin 2 (LCN2) 蛋白
    Lipocalin 2 (LCN2)
    蛋白类型
    Native
    产品特性
    full length
    宿主
    • 13
    • 6
    • 5
    • 2
    • 1
    • 1
    资源
    • 11
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    应用范围
    Western Blotting (WB), SDS-PAGE (SDS), ELISA, Latex enhanced turbidimetric Immunoassay (LETIA)
    纯化方法
    Purified from human urine
    纯度
    > 95 %(SDS-PAGE)
    Top Product
    Discover our top product LCN2 蛋白
  • 应用备注
    calibrator ,immunogen and other possible
    说明

    Full length native Neutrophil gelatinase-associated lipocalin protein

    限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS
    储存条件
    -20 °C
  • 抗原
    Lipocalin 2 (LCN2)
    别名
    Neutrophil gelatinase-associated lipocalin (LCN2 产品)
    背景
    Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
    途径
    Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis
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