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Human Polyclonal NUP155 Primary Antibody for WB - ABIN541368
Radu, Blobel, Wozniak: Nup155 is a novel nuclear pore complex protein that contains neither repetitive sequence motifs nor reacts with WGA. in The Journal of cell biology 1993
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These human and mouse studies indicate that loss of NUP155 function causes atrial fibrillation by altering mRNA and protein transport and link the nuclear pore complex to cardiovascular disease.
Self-interaction between the N- and C-terminal domains of Nup155 has an auto-inhibitory function that prevents interaction between the N-terminus of Nup155 and the C-terminal region of Nup53. Nup93 can overcome this block by binding to Nup53, thereby promoting formation of the inner ring and the nuclear pore complexes.
The interaction of Nup53 and Nup155 has a crucial role in nuclear pore complex formation.
In vivo depletion of Nup155 led to failure of nuclear lamina formation and defects in chromosome segregation at anaphase.
The Nup155-mediated localization was required for HDAC4's effect on gene expression.
The Nup155 depletion massively alters nuclear envelope structure, causing a dramatic decrease in Nuclear pore complexes numbers and the improper targeting of membrane proteins to the inner nuclear membrane.
Nucleoporins are the main components of the nuclear pore complex (NPC) of eukaryotic cells. They are involved in the bidirectional trafficking of molecules, especially mRNAs and proteins, between the nucleus and the cytoplasm. The protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. Two protein isoforms are encoded by transcript variants of this gene.
, nuclear pore protein
, nuclear pore complex protein Nup155-like
, 155 kDa nucleoporin
, nuclear pore complex protein Nup155
, nucleoporin Nup155
, nucleoporin 155kD