This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine. [provided by RefSeq, Jul 2008].
Sherman-Baust, Becker, Wood Iii, Zhang, Morin: "Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin." in: Journal of ovarian research, Vol. 4, Issue 1, pp. 21, (2012) (PubMed).
Chen, Hodge, Guarda, Welch, Greenberg, Chai: "Down-regulation of prostasin serine protease: a potential invasion suppressor in prostate cancer." in: The Prostate, Vol. 48, Issue 2, pp. 93-103, (2001) (PubMed).
Chen, Skinner, Kauffman, Chao, Chao, Thaler, Chai: "Prostasin is a glycosylphosphatidylinositol-anchored active serine protease." in: The Journal of biological chemistry, Vol. 276, Issue 24, pp. 21434-42, (2001) (PubMed).
Yu, Chao, Chao: "Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA." in: The Journal of biological chemistry, Vol. 270, Issue 22, pp. 13483-9, (1995) (PubMed).
Yu, Chao, Chao: "Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland." in: The Journal of biological chemistry, Vol. 269, Issue 29, pp. 18843-8, (1994) (PubMed).