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Programmed Cell Death 1 蛋白

(Programmed Cell Death 1 (PDCD1))
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008].

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  • 抗原: PD-1 (PDCD1)
  • Protein
Catalog no. 产品 适用 宿主 / 克隆类型 应用 价格和交货时间
ABIN6992382
PD-1 Protein (AA 25-167) (His tag) PDCD1 · Protein 猕猴 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
  • 100 μg
  • 1 mg
发货至: 中国
ABIN7273346
PD-1 Protein (AA 25-288) (His tag) PDCD1 · Protein 人 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
  • 100 μg
  • 20 μg
  • 500 μg
发货至: 中国
ABIN2181603
PD-1 Protein (AA 25-167) (Fc Tag) PDCD1 · Protein Cynomolgus HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
  • 100 μg
  • 1 mg
发货至: 中国
ABIN2181593
PD-1 Protein (AA 25-167) (His tag,AVI tag,Biotin) PDCD1 · Protein 人 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • Bind (Binding Studies: 有验证图片)
  • 200 μg
  • 25 μg
发货至: 中国
ABIN2181617
PD-1 Protein (AA 25-167) (Fc Tag) PDCD1 · Protein 小鼠 HEK-293 Cells
  • SDS (SDS-PAGE: 有验证图片)
  • Bind (Binding Studies: 有验证图片)
  • 100 μg
  • 1 mg
发货至: 中国
ABIN7889945
PD-1 Protein (AA 25-167) (His tag) PDCD1 · Protein 人 人细胞
  • 10 μg
发货至: 中国
ABIN7889944
PD-1 Protein (AA 25-167) (His tag) PDCD1 · Protein 大鼠 人细胞
  • 1 mg
发货至: 中国
ABIN7535693
PD-1 Protein (His tag) PDCD1 · Protein 大鼠 HEK-293 Cells
  • 100 μg
  • 1 mg
  • 10 μg
  • 20 μg
  • 50 μg
  • 500 μg
发货至: 中国
ABIN6253230
PD-1 Protein (AA 25-167, C-Term, Extracellular Domain) (His tag) PDCD1 · Protein 人 HEK-293 Cells
  • 100 μg
  • 997 g
发货至: 中国
ABIN6253229
PD-1 Protein (AA 25-167, Extracellular Domain) PDCD1 · Protein 人 HEK-293 Cells
  • 50 μg
  • 993 g
发货至: 中国
ABIN6253234
PD-1 Protein (AA 26-169, Extracellular Domain) (Fc Tag) PDCD1 · Protein 小鼠 HEK-293 Cells
  • 100 μg
  • 997 g
发货至: 中国
ABIN4371923
PD-1 Protein (AA 25-167, C93S) (Fc Tag) PDCD1 · Protein 人 人细胞
  • 50 μg
  • 1 mg
  • 10 μg
  • 500 μg
发货至: 中国
ABIN7504502
PD-1 Protein (AA 25-170) (hFc Tag) PDCD1 · Protein 犬 HEK-293 Cells
  • 100 μg
  • 500 μg
发货至: 中国
ABIN7677580
PD-1 Protein (AA 21-170) (Fc Tag) PDCD1 · Protein 人 HEK-293 Cells
  • SDS (SDS-PAGE: 所列应用)
  • AcA (Activity Assay: 所列应用)
  • 100 μg
  • 10 μg
  • 20 μg
  • 50 μg
  • 250 μg
  • 500 μg
发货至: 中国
ABIN7852726
PD-1 Protein (AA 25-168) (mFc Tag) PDCD1 · Protein 犬 HEK-293 Cells
  • ScA (Screening Assay: 所列应用)
  • AM (Affinity Measurement: 所列应用)
  • ADA (Antibody Drug Assay: 所列应用)
  • IA (Immunoassay: 所列应用)
  • 100 μg
  • 10 μg
  • 50 μg
发货至: 中国
ABIN7852730
PD-1 Protein (AA 25-168) (Fc Tag) PDCD1 · Protein 犬 HEK-293 Cells
  • ScA (Screening Assay: 所列应用)
  • AM (Affinity Measurement: 所列应用)
  • ADA (Antibody Drug Assay: 所列应用)
  • IA (Immunoassay: 所列应用)
  • 100 μg
  • 10 μg
  • 50 μg
发货至: 中国
ABIN7852724
PD-1 Protein (AA 25-168) (His tag) PDCD1 · Protein 犬 HEK-293 Cells
  • ScA (Screening Assay: 所列应用)
  • AM (Affinity Measurement: 所列应用)
  • ADA (Antibody Drug Assay: 所列应用)
  • IA (Immunoassay: 所列应用)
  • 100 μg
  • 10 μg
  • 50 μg
发货至: 中国
ABIN7853540
PD-1 Protein (AA 25-145) (Fc Tag) PDCD1 · Protein 人 HEK-293 Cells
  • ScA (Screening Assay: 所列应用)
  • AM (Affinity Measurement: 所列应用)
  • ADA (Antibody Drug Assay: 所列应用)
  • IA (Immunoassay: 所列应用)
  • 100 μg
  • 10 μg
  • 50 μg
发货至: 中国
ABIN7865932
PD-1 Protein (hFc-Avi Tag,Biotin) PDCD1 · Protein 人 HEK-293 Cells
  • 50 μg
发货至: 中国
ABIN7865933
PD-1 Protein (His-Avi Tag,Biotin) PDCD1 · Protein 人 HEK-293 Cells
  • 50 μg
发货至: 中国
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
宿主
猕猴
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>90 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN6992382
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>80 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN7273346
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • ELISA (ELISA: 有验证图片)
宿主
Cynomolgus
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>90 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN2181603
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • Bind (Binding Studies: 有验证图片)
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN2181593
200 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 有验证图片)
  • Bind (Binding Studies: 有验证图片)
宿主
小鼠
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % as determined by SDS-PAGE.
生物活性
Active
产品编号 ABIN2181617
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
人细胞
蛋白类型
Recombinant
产品编号 ABIN7889945
Protein
宿主
大鼠
宿主
人细胞
蛋白类型
Recombinant
产品编号 ABIN7889944
Protein
宿主
大鼠
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
> 95 % by SDS-PAGE.
产品编号 ABIN7535693
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % (SDS-PAGE)
生物活性
Active
产品编号 ABIN6253230
Protein
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % (SDS-PAGE)
生物活性
Active
产品编号 ABIN6253229
Protein
宿主
小鼠
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % (SDS-PAGE)
产品编号 ABIN6253234
Protein
宿主
人
宿主
人细胞
蛋白类型
Recombinant
纯度
> 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN4371923
50 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
犬
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
> 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
生物活性
Active
产品编号 ABIN7504502
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • SDS (SDS-PAGE: 所列应用)
  • AcA (Activity Assay: 所列应用)
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
> 95 %
生物活性
Active
产品编号 ABIN7677580
Protein
  • ScA (Screening Assay: 所列应用)
  • AM (Affinity Measurement: 所列应用)
  • ADA (Antibody Drug Assay: 所列应用)
  • IA (Immunoassay: 所列应用)
宿主
犬
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
产品编号 ABIN7852726
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • ScA (Screening Assay: 所列应用)
  • AM (Affinity Measurement: 所列应用)
  • ADA (Antibody Drug Assay: 所列应用)
  • IA (Immunoassay: 所列应用)
宿主
犬
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
产品编号 ABIN7852730
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • ScA (Screening Assay: 所列应用)
  • AM (Affinity Measurement: 所列应用)
  • ADA (Antibody Drug Assay: 所列应用)
  • IA (Immunoassay: 所列应用)
宿主
犬
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
产品编号 ABIN7852724
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
  • ScA (Screening Assay: 所列应用)
  • AM (Affinity Measurement: 所列应用)
  • ADA (Antibody Drug Assay: 所列应用)
  • IA (Immunoassay: 所列应用)
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
产品编号 ABIN7853540
100 μg (More quantities available)
发货至: 中国
获取报价
Protein
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % , as determined by SDS-PAGE and HPLC
产品编号 ABIN7865932
Protein
宿主
人
宿主
HEK-293 Cells
蛋白类型
Recombinant
纯度
>95 % , as determined by SDS-PAGE and HPLC
产品编号 ABIN7865933

Latest Publications for our Programmed Cell Death 1 蛋白

Assi, Wong, Tipton, Mei, Wong, Razo, Chan, Howng, Sagert, Krimm, Diep, Jang, Nguyen, Lapuyade, Singson, Villanueva, Paidhungat, Liu, Rangan, Vasiljeva, West, Richardson, Irving, Daniel, Belvin et al.: "Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 Agents. ..." in: Cancer immunology research, Vol. 9, Issue 12, pp. 1451-1464, (2022) (PubMed).

Curnock, Bossi, Kumaran, Bawden, Figueiredo, Tawar, Wiseman, Henderson, Hoong, Gonzalez, Ghadbane, Knight, ODwyer, Overton, Lucato, Smith, Reis, Page, Whaley, McCully, Hearty, Mahon, Weber: "Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors." in: JCI insight, Vol. 6, Issue 20, (2021) (PubMed).

Bai, Gao, Hu, Liu, Li, Dong, Huang, Zhu, Zhou, Li, Shao: "Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth." in: Molecular therapy oncolytics, Vol. 17, pp. 9-20, (2020) (PubMed).

Wang, Kang, Chen, Jehng, Jones, Chen, Huang, Chen: "An engineered oncolytic virus expressing PD-L1 inhibitors activates tumor neoantigen-specific T cell responses." in: Nature communications, Vol. 11, Issue 1, pp. 1395, (2020) (PubMed).

Fan, Tian, Chen, Liu, Zhou, He, Coleman, Dong, Li, Huang, Xu, Zhang, Gao, Zhou, Ding, Chen: "Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors." in: EMBO molecular medicine, Vol. 12, Issue 6, pp. e11571, (2020) (PubMed).

Wang, Ni, Zhou, He, Gao, Wu, Wu, Wu, Qiu, Zhou, Chen, Pan, Huang, Li, Bian, Yang, Miao, Liu: "Tumor-selective blockade of CD47 signaling with a CD47/PD-L1 bispecific antibody for enhanced anti-tumor activity and limited toxicity." in: Cancer immunology, immunotherapy : CII, (2020) (PubMed).

Wang, Fei, Jing, Wu, Wu, Zhou, Ni, Chen, Xiong, Liu, Peng, Yu, Jiang, Liu: "Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit." in: mAbs, (2019) (PubMed).

Ganesan, Ahmed, Okoye, Arutyunova, Babu, Turnbull, Kundu, Shields, Agopsowicz, Xu, Tabana, Srivastava, Zhang, Moon, Belovodskiy, Hena, Kandadai, Hosseini, Hitt, Walker, Smylie, West, Siraki, Lemieux et al.: "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors. ..." in: Scientific reports, Vol. 9, Issue 1, pp. 12392, (2019) (PubMed).

Son, Park, Seo, Lee, Heo, Kim: "A small-sized protein binder specific for human PD-1 effectively suppresses the tumour growth in tumour mouse model." in: Journal of drug targeting, pp. 1-9, (2019) (PubMed).

Galstyan, Markman, Shatalova, Chiechi, Korman, Patil, Klymyshyn, Tourtellotte, Israel, Braubach, Ljubimov, Mashouf, Ramesh, Grodzinski, Penichet, Black, Holler, Sun, Ding, Ljubimov, Ljubimova: "Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy." in: Nature communications, Vol. 10, Issue 1, pp. 3850, (2019) (PubMed).

Aliases for Programmed Cell Death 1 蛋白

programmed cell death 1 (PDCD1) 蛋白
programmed cell death 1 (Pdcd1) 蛋白
CD279 蛋白
hPD-1 蛋白
hPD-l 蛋白
Ly101 蛋白
PD-1 蛋白
PD1 蛋白
Pdc1 蛋白
SLEB2 蛋白
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