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Presenilin 1 产品

(Presenilin 1 (PSEN1))
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1\; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008].

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Featured Presenilin 1 Categories

Presenilin 1 抗体

High quality antibodies with extensive validation data.

Presenilin 1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

Presenilin 1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Presenilin 1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (6)
Cat. No. ABIN3023160
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p), IF, FACS
Validations
  • (1)
  • (4)
Cat. No. ABIN390169
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN7164264
Quantity 100 μg
Datasheet Datasheet

Recommended Presenilin 1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6958721
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969495
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958722
Quantity 96 tests
Datasheet Datasheet

Recommended Presenilin 1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316518
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3086647
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3134271
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our Presenilin 1 Products

Puri, Yerrathota, Home, Idowu, Chakravarthi, Ward, Singhal, Vanden Heuvel, Fields, Sharma: "Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy." in: Disease models & mechanisms, Vol. 12, Issue 12, (2020) (PubMed).

Dursun, Gezen-Ak: "Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin." in: PLoS ONE, Vol. 12, Issue 11, pp. e0188605, (2017) (PubMed).

Chu, Peng, Long, Wang, Luo, Sharma, He: "Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 4, pp. 258-66, (2015) (PubMed).

Paulasir, Kaoutzanis, Welch, Vandewarker, Krapohl, Lampman, Franz, Cleary: "Nonsteroidal Anti-inflammatory Drugs: Do They Increase the Risk of Anastomotic Leaks Following Colorectal Operations?" in: Diseases of the colon and rectum, Vol. 58, Issue 9, pp. 870-7, (2015) (PubMed).

Luciano, Barraco, Muraca, Ottino, Spreghini, Sforza, Rustico, Morino, Manco: "Biomarkers of Alzheimer disease, insulin resistance, and obesity in childhood." in: Pediatrics, Vol. 135, Issue 6, pp. 1074-81, (2015) (PubMed).

Lefort, Pozueta, Shelanski: "Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 31, pp. 10674-85, (2012) (PubMed).

Scarpi, Cirelli, Matrone, Castronovo, Rosini, Occhiato, Romano, Bartali, Clemente, Bottegoni, Cavalli, De Chiara, Bonini, Calissano, Palamara, Garaci, Torcia, Guarna, Cozzolino: "Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity." in: Cell death & disease, Vol. 3, pp. e389, (2012) (PubMed).

Lombardo, Filipović, Molyneux, Periyasamy, Giamas, Hu, Trivedi, Wang, Yagüe, Michel, Coombes: "Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 41, pp. 16558-63, (2012) (PubMed).

Nie, Li, Yan, Wang, Zhao, Guo, Yin: "Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-?4?2 nAChR-APP695 cells." in: Neurochemical research, Vol. 36, Issue 5, pp. 904-12, (2011) (PubMed).

McCombs, Gibson, Palmer: "Using a genetically targeted sensor to investigate the role of presenilin-1 in ER Ca2+ levels and dynamics." in: Molecular bioSystems, Vol. 6, Issue 9, pp. 1640-9, (2010) (PubMed).

Synonyms and alternative names related to Presenilin 1

presenilin 1 (psen1), presenilin 1 (PSEN1), presenilin 1 (Psen1), presenilin 1 L homeolog (psen1.L), ad3, AD3, Ad3h, fad, FAD, pre1, PS-1, ps1, PS1, psen, s182, S182, X-PS-alpha, X-PS-beta, zf-PS1, zfPS1

Protein level used designations for Presenilin 1

  • PS-1
  • presenilin-1
  • presenilin 1 (Alzheimer disease 3)
  • presenilin-1 isoform I-463
  • presenilin-1 isoform I-467
  • presenilin 1
  • presenilin-1-like
  • PS-alpha
  • presenilin alpha
  • presenilin-alpha
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