The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Kuo, Huang, Yang, Yang, Lee, Chiang: "Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt." in: The Journal of biological chemistry, Vol. 283, Issue 4, pp. 1882-92, (2008) (PubMed).
Lin, Bassik, Suh, Nishino, Arroyo, Hahn, Korsmeyer, Roberts: "PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum." in: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23003-12, (2006) (PubMed).
Kumamoto: "A contact-activated kinase signals Candida albicans invasive growth and biofilm development." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 15, pp. 5576-81, (2005) (PubMed).
Aliases for PPP2R5C 抗体
protein phosphatase 2 regulatory subunit B'gamma (PPP2R5C) 抗体 protein phosphatase 2, regulatory subunit B', gamma (Ppp2r5c) 抗体 protein phosphatase 2 regulatory subunit B', gamma (ppp2r5c) 抗体 protein phosphatase 2 regulatory subunit B', gamma (ppp2r5c.L) 抗体 protein phosphatase 2, regulatory subunit B', gamma b (ppp2r5cb) 抗体 protein phosphatase 2, regulatory subunit B', gamma a (ppp2r5ca) 抗体 protein phosphatase 2 regulatory subunit B'gamma (Ppp2r5c) 抗体 2610043M05Rik 抗体 2700063L20Rik 抗体 AI060890 抗体 AW545884 抗体 B56G 抗体 b56g 抗体 C85228 抗体 D12Bwg0916e 抗体 mKIAA0044 抗体 ppp2r5c 抗体 PR61G 抗体 si:dkey-241l7.9 抗体