The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008].
Cristóbal, Garcia-Orti, Cirauqui, Alonso, Calasanz, Odero: "PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect." in: Leukemia, Vol. 25, Issue 4, pp. 606-14, (2011) (PubMed).
McCright, Virshup: "Identification of a new family of protein phosphatase 2A regulatory subunits." in: The Journal of biological chemistry, Vol. 270, Issue 44, pp. 26123-8, (1995) (PubMed).
Aliases for PPP2R5B 抗体
protein phosphatase 2 regulatory subunit B'beta (PPP2R5B) 抗体 protein phosphatase 2, regulatory subunit B', beta (Ppp2r5b) 抗体 protein phosphatase 2A regulatory subunit B' (PPP2R5B) 抗体 protein phosphatase 2 regulatory subunit B', beta (ppp2r5b) 抗体 protein phosphatase 2 regulatory subunit B', beta (ppp2r5b.L) 抗体 protein phosphatase 2 regulatory subunit Bbeta (PPP2R2B) 抗体 B'beta 抗体 B56B 抗体 BC026670 抗体 PPP2R5B 抗体 ppp2r5e 抗体 PR61B 抗体