PPM1F 抗体
(Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008].
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Latest Publications for our PPM1F 抗体
: "Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts." in: The Journal of biological chemistry, Vol. 279, Issue 23, pp. 24889-98, (2004) (PubMed).: "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages." in: Nature medicine, Vol. 9, Issue 2, pp. 191-7, (2003) (PubMed).
: "The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family." in: Current biology : CB, Vol. 12, Issue 4, pp. 317-21, (2002) (PubMed).
: "The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis." in: The Journal of biological chemistry, Vol. 276, Issue 47, pp. 44193-202, (2001) (PubMed).
: "Molecular cloning of Ca2+/calmodulin-dependent protein kinase phosphatase." in: Journal of biochemistry, Vol. 125, Issue 6, pp. 1022-8, (1999) (PubMed).
Aliases for PPM1F 抗体
protein phosphatase, Mg2+/Mn2+ dependent 1F (PPM1F) 抗体protein phosphatase 1F (PP2C domain containing) (Ppm1f) 抗体
protein phosphatase, Mg2+/Mn2+ dependent, 1F (Ppm1f) 抗体
1110021B16Rik 抗体
4933427B07Rik 抗体
CAMKP 抗体
CaMKPase 抗体
FEM-2 抗体
hFEM-2 抗体
mKIAA0015 抗体
Popx2 抗体
POPX2 抗体
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