The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008].
Mulay, Honarpisheh, Foresto-Neto, Shi, Desai, Zhao, Marschner, Popper, Buhl, Boor, Linkermann, Liapis, Bilyy, Herrmann, Romagnani, Belevich, Jokitalo, Becker, Anders: "Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI." in: Journal of the American Society of Nephrology : JASN, (2019) (PubMed).
Wang, Lin, Chen, Zhu, Jiang, Li, Wang et al.: "Overexpression of mitochondrial Hsp75 protects neural stem cells against microglia-derived soluble factor-induced neurotoxicity by regulating mitochondrial permeability transition pore opening in ..." in: International journal of molecular medicine, Vol. 36, Issue 6, pp. 1487-96, (2016) (PubMed).
Bowles, Abraham, Brugada, Zintz, Comeaux, Sorajja, Tsubata, Li, Brandon, Gibbs, Scherer, Bowles, Towbin: "Construction of a high-resolution physical map of the chromosome 10q22-q23 dilated cardiomyopathy locus and analysis of candidate genes." in: Genomics, Vol. 67, Issue 2, pp. 109-27, (2000) (PubMed).
Aliases for PPIF 抗体
peptidylprolyl isomerase F (PPIF) 抗体 peptidylprolyl isomerase Fa (ppifa) 抗体 peptidylprolyl isomerase F (cyclophilin F) (Ppif) 抗体 peptidylprolyl isomerase F (Ppif) 抗体 peptidylprolyl isomerase D (Ppid) 抗体 peptidylprolyl isomerase F (ppif) 抗体 peptidylprolyl isomerase F L homeolog (ppif.L) 抗体 AW457192 抗体 Cyp-40 抗体 Cyp-D 抗体 CyP-D 抗体 CyP-F 抗体 CyP-M 抗体 CYP3 抗体 CypD 抗体 cypf 抗体 PPIase 抗体 ppif 抗体 wu:fd61c06 抗体 zgc:101753 抗体