The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008].
Nguyen, Stevens, Kohr, Steenbergen, Sack, Murphy: "Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore." in: The Journal of biological chemistry, Vol. 286, Issue 46, pp. 40184-92, (2011) (PubMed).
McGee, Baines: "Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death." in: The Biochemical journal, Vol. 433, Issue 1, pp. 119-25, (2010) (PubMed).
Aliases for PPID 蛋白
peptidylprolyl isomerase D (PPID) 蛋白 peptidylprolyl isomerase D (Ppid) 蛋白 peptidylprolyl isomerase D (ppid) 蛋白 peptidylprolyl isomerase D (cyclophilin D) (Ppid) 蛋白 peptidylprolyl isomerase D (cyclophilin D) S homeolog (ppid.S) 蛋白 4930564J03Rik 蛋白 CYP-40 蛋白 Cyp-40 蛋白 cyp-40 蛋白 CYPD 蛋白 CypD 蛋白 cypd 蛋白 PPID 蛋白 Ppidl 蛋白 Ppif 蛋白 wu:fb18b07 蛋白 zgc:86711 蛋白