The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009].
Gegunde, Alfonso, Alvariño, Alonso, Botana: "Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions." in: Frontiers in immunology, Vol. 12, pp. 609196, (2021) (PubMed).
Ray, Sullenger, White: "Further characterization of the target of a potential aptamer biomarker for pancreatic cancer: cyclophilin B and its posttranslational modifications." in: Nucleic acid therapeutics, Vol. 23, Issue 6, pp. 435-42, (2013) (PubMed).
Aliases for PPIB 蛋白
peptidylprolyl isomerase B (ppib) 蛋白 peptidylprolyl isomerase B (PPIB) 蛋白 peptidylprolyl isomerase B (Ppib) 蛋白 peptidylprolyl isomerase B (CC1G_03223) 蛋白 peptidylprolyl isomerase B (cyclophilin B) (Ppib) 蛋白 peptidylprolyl isomerase B L homeolog (ppib.L) 蛋白 peptidylprolyl isomerase B (cyclophilin B) (PPIB) 蛋白 peptidylprolyl isomerase B (cyclophilin B) (ppib) 蛋白 AA408962 蛋白 AA553318 蛋白 ACYPI004891 蛋白 AI844835 蛋白 cb87 蛋白 Cphn-2 蛋白 Cphn2 蛋白 CyP-20b 蛋白 cyp-s1 蛋白 CYP-S1 蛋白 cypb 蛋白 CypB 蛋白 CYPB 蛋白 OI9 蛋白 PPIB 蛋白 Ppib 蛋白 sb:cb87 蛋白 scylp 蛋白 Scylp 蛋白 SCYLP 蛋白 wu:fa97f08 蛋白 zgc:73214 蛋白 zgc:86796 蛋白