This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq, Jul 2008].
Kutuzov, Soloveva, Andreeva, Bennett: "Protein Ser/Thr phosphatases PPEF interact with calmodulin." in: Biochemical and biophysical research communications, Vol. 293, Issue 3, pp. 1047-52, (2002) (PubMed).
Ramulu, Kennedy, Xiong, Williams, Cowan, Blesh, Yau, Hurley, Nathans: "Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2)." in: Molecular and cellular biology, Vol. 21, Issue 24, pp. 8605-14, (2001) (PubMed).
Herzig, Neumann: "Effects of serine/threonine protein phosphatases on ion channels in excitable membranes." in: Physiological reviews, Vol. 80, Issue 1, pp. 173-210, (2000) (PubMed).
Aliases for PPEF1 抗体
protein phosphatase with EF-hand domain 1 (PPEF1) 抗体 protein phosphatase with EF-hand domain 1 (ppef1) 抗体 protein phosphatase with EF hand calcium-binding domain 1 (Ppef1) 抗体 protein phosphatase with EF-hand domain 1 (Ppef1) 抗体 serine/threonine phosphatase 7 (PP7) 抗体 ATPP7 抗体 MGI19.12 抗体 MGI19_12 抗体 PP7 抗体 PPEF 抗体 PPEF-1 抗体 PPEF1 抗体 PPP7C 抗体 PPP7CA 抗体 serine/threonine phosphatase 7 抗体