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Targeting FOXM1 with thiostrepton decreased FOXM1 mRNA expression and its downstream targets such as CCNB1 (显示 CCNB1 ELISA试剂盒) and CDC25B (显示 CDC25B ELISA试剂盒), leading to cell death in both cell lines and patients' ascites cancer cells.
these results demonstrate that the reversible acetylation of FOXM1 by p300/CBP (显示 CREBBP ELISA试剂盒) and SIRT1 (显示 SIRT1 ELISA试剂盒) modulates its transactivation function
this study shows that FOXM1 confers resistance to gefitinib in lung adenocarcinoma via a MET/AKT (显示 AKT1 ELISA试剂盒)-dependent positive feedback loop
FOXM1 has roles in cell cycle, pluripotency genes and stem cell pathways in sarcoma [review]
Cells with ectopic FOXM1 expression demonstrate considerable ( approximately 20%, P < 0.001) growth advantage despite MET targeting.
FoxM1 is an established therapeutic target for several cancers.
Data indicate that forkhead box M1 (FOXM1) is highly expressed in the erythroid population suggesting a role of FOXM1 in erythropoiesis.
this study provided mechanistic evidences to support the positive regulatory function of FOXM1 in HSPA5 (显示 HSPA5 ELISA试剂盒) expression in colorectal cancer
We identified FOXM1 and FOXQ1 (显示 FOXQ1 ELISA试剂盒) as novel prognostic biomarkers in colorectal cancer and miR (显示 MLXIP ELISA试剂盒)-342 as a novel regulator of both FOXM1 and FOXQ1 (显示 FOXQ1 ELISA试剂盒)
High FOXM1 expression is associated with malignant pleural mesothelioma.
Upregulated ROS (显示 ROS1 ELISA试剂盒) induced by FABP4 (显示 FABP4 ELISA试剂盒) was of significance in activating FoxM1 leading to airway inflammation and epithelial barrier dysfunction.
Interactions between the Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) and the Kras/ERK (显示 EPHB2 ELISA试剂盒)/Foxm1 pathways are essential to restrict SOX9 (显示 SOX9 ELISA试剂盒) expression in basal cells during pulmonary branching morphogenesis
YAP (显示 YAP1 ELISA试剂盒) cooperates with FOXM1 to contribute to chromosome instability in hepatocellular carcinoma.
RCM-1 (显示 TNNI3 ELISA试剂盒) blocked the nuclear localization and increased the proteasomal degradation of Forkhead box M1 (FOXM1), a transcription factor critical for the differentiation of goblet cells from airway progenitor cells.
These data implicate the insulin (显示 INS ELISA试剂盒)-FoxM1/PLK1 (显示 PLK1 ELISA试剂盒)/CENP-A (显示 CENPA ELISA试剂盒) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.
EGF (显示 EGF ELISA试剂盒) promotes FoxM1 expression through the ERK (显示 EPHB2 ELISA试剂盒) signal pathway
FoxM1 induction in the pulmonary vasculature was inhibited by a p110gamma (显示 PIK3CG ELISA试剂盒)-selective inhibitor and in Pik3cg (显示 PIK3CG ELISA试剂盒)(-/-) mice after LPS (显示 TLR4 ELISA试剂盒) challenge. Defective vascular repair in Pik3cg (显示 PIK3CG ELISA试剂盒)-/- mice results from impaired FoxM1 expression
we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstream of Hoxa10 (显示 HOXA10 ELISA试剂盒) and cyclin D3 (显示 CCND3 ELISA试剂盒).
FOXM1 and CENPF (显示 CENPF ELISA试剂盒) are master regulators of prostate cancer malignancy, and can serve as drug response markers for antineoplastic drugs efficiency.
Both gain-of-function and loss-of-function TP53 (显示 TP53 ELISA试剂盒) mutations contribute to overexpression of FoxM1 in high-grade serous ovarian cancer.
the sequence and expression pattern of FoxM1 (fork head box M1) transcription factor in Xenopus laevis embryos are described
Results suggest that FoxM1 functions to link cell division and neuronal differentiation in early Xenopus embryos.
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene.
forkhead box protein M1
, forkhead box M1
, forkhead box protein M1-like
, Forkhead, drosophila, homolog-like 16
, HNF-3/fork-head homolog 11
, M-phase phosphoprotein 2
, MPM-2 reactive phosphoprotein 2
, forkhead-related protein FKHL16
, hepatocyte nuclear factor 3 forkhead homolog 11
, transcription factor Trident
, winged-helix factor from INS-1 cells
, forkhead homolog 16
, winged-helix transcription factor Trident
, INS-1 winged helix