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抗Human Urocortin 抗体:
抗Rat (Rattus) Urocortin 抗体:
抗Mouse (Murine) Urocortin 抗体:
These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 (显示 CRHR1 抗体) and CRHR2 (显示 CRHR2 抗体) and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
Results describe the distribution of urotensin I, UIIalpha and UIIbeta mRNAs in different organs and the cellular localization of the three mRNAs in the spinal cord by in situ hybridization (ISH (显示 ANTXR2 抗体)) histochemistry.
Study found reduced miR (显示 MLXIP 抗体)-326 levels concomitant with elevated Ucn1 levels in Edinger-Westphal nucleus (EWcp) of depressed suicide completers and in the EWcp of depressed rats. In fully recovered rats, both serum and EWcp miR (显示 MLXIP 抗体)-326 levels rebounded to nonstressed levels. While downregulation of miR (显示 MLXIP 抗体)-326 levels in primary midbrain neurons enhanced Ucn1 expression levels, miR (显示 MLXIP 抗体)-326 overexpression selectively reduced its levels.
In deep infiltrating endometriotic lesions, CRH (显示 CRH 抗体), Ucn and CRH-R2 (显示 CRHR2 抗体) mRNA levels were significantly higher than in ovarian endometrioma.
UCN I is secreted from human glioblastoma cells by exocytosis through constitutive secretory granules.
Findings identify Ucn as a potential mediator that inhibits TGFbeta1 (显示 TGFB1 抗体) oncogenic signaling in breast neoplasm.
In women with adnexal endometrioma versus teratoma (显示 DND1 抗体), the medians were 105.31 pg/mL versus 120.84 pg/mL for urocortin, 7.16 pg/mL versus 9.13 pg/mL for leptin (显示 LEP 抗体) and 584.33 pg/mL versus 657.82 pg/mL for ghrelin (显示 GHRL 抗体) (p > 0.05), respectively.
Ucn1 prevents the development of atherosclerosis by suppressing EC inflammatory response and proliferation, macrophage foam cell formation, and VSMC migration and proliferation
These data suggest that UVB-stimulated Ucn1 contributes to TRP1 (显示 PRSS1 抗体) production via the transcription of both Nurr-1 (显示 NR4A2 抗体) and Nur77 (显示 NR4A1 抗体). Ucn1, produced in melanoma cells, acts on melanoma cells themselves in an autocrine manner.
Production of CRF (显示 CRH 抗体) and UCN1 in human dendritic cells is strongly augmented by commensal intestinal bacteria.
Cardioplegic arrest failed to induce cardiac myocyte overexpression of urocortin in diabetic hearts.
Urocortin expression inversely correlates with higher tumor grade and advanced tumor stage in gastric adenocarcinomas.
Genetic deletion of Ucn1 reduced high levels of intake and preference across 2 weeks of continuous access drinking when alcohol concentrations were increased from 10 to 20 to 40%. Ucn1 deletion did not alter low-level drinking when the alcohol concentration remained at 10%.
Taken together, our data indicate that sex shows significant interaction with genotype and Ucn1 during colitis. Human duodenal and colonic biopsies revealed that sex-specific differences exist in levels of CRF receptors and Ucn1 expression in patients with CD compared with the matched non-IBD subjects. To conclude, Ucn1 mediates sex-specific immune and cellular signaling responses via CRF2, emphasizing the need for inclus
it is shown that CRH (显示 CRH 抗体) and UCN upregulate galectin-1 (显示 LGALS1 抗体) expression in Ishikawa cell line and macrophages and this effect is mediated through CRHR1 (显示 CRHR1 抗体).
This study aims to investigate the cellular localization of CRF (显示 CRH 抗体) and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
CNTF (显示 CNTF 抗体) activates hypothalamic urocortin 1-expressing neurons both in vitro and in vivo.
The absence of the CB1 (显示 CNR1 抗体) receptor alters the Ucn1 mRNA and peptide levels in Edinger-Westphal nucleus neurones, concomitant with an augmented stress response and increased anxiety-like behaviour.
EWcp-Ucn1 neurons play an important role in EtOH intake, preference, and reward.
CRF(1) agonists, Ucn 1 and stressin(1) -A, reduced feeding and induced interoceptive stress, whereas Ucn 2 potently suppressed feeding via a CRF(2) -dependent mechanism without eliciting malaise
Data suggest that UCN regulates osteoclast resorption by suppressing osteoclast maturation/function via suppression of constitutively active cation channel (显示 TRPV1 抗体) (CRFR2beta (显示 CRHR2 抗体)) with properties of canonical transient receptor potential 1 (TRPC1 (显示 TRPC1 抗体)) channel.
Ucn1 gene was downregulated in 5-HTT (显示 SLC6A4 抗体) KO and upregulated in 5-HTT (显示 SLC6A4 抗体) TG mice which exhibit opposite changes in anxiety-related behavior; findings suggesti this peptide can be involved in behavioral changes observed in 5-HTT (显示 SLC6A4 抗体) mutant mice
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.
, urocortin, preproprotein