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Dapper1 attenuates hepatic gluconeogenesis and lipogenesis in Ttype 2 diabetes.
Dpr1 promotes the ubiquitination of Dvl2 (显示 DVL2 蛋白) by pVHL (显示 VHL 蛋白) and mediates the protein aggregate-elicited autophagy initiation
Expression analysis of Dact1-LacZ (显示 GLB1 蛋白) show high expression levels in multiple mesoderm- and neuroectoderm-derived tissues during embryonic development, but restricted to a small number of postnatal tissues.
These results support a novel cell-autonomous postsynaptic role for Dact1, in cooperation with Dishevelled-1 (显示 DVL1 蛋白) and possibly Disrupted in Schizophrenia-1 (显示 DISC1 蛋白), in the formation of synapses on cortical interneuron dendrites.
Depletion of Dapper-1 and dishevelled-2 (显示 DVL2 蛋白) in cardiomyocytes demonstrated that Dapper-1 functions upstream of dishevelled-2 (显示 DVL2 蛋白) and that activity of both Dapper-1 and dishevelled-2 (显示 DVL2 蛋白) is essential for activating canonical Wnt (显示 WNT2 蛋白) signaling.
conserved role for Dact1 protein in kinase-regulated biochemistry involving Vangl and Dvl (显示 DVL1 蛋白).
Dact1 was upregulated in the dental follicle mesenchyme at the cap stage and subsequently also in the dental papilla at the bell stage, where the expression persisted to the postnatal stages.
Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled (显示 DVL2 蛋白) activity and leads to posterior malformation in mice.
This study shown that Dact1 plays an important role during dendrite and spine formation in neurons of the mammalian forebrain by promoting activation of Rac (显示 AKT1 蛋白)
Frodo is expressed in primitive streak mesoderm, neuroectoderm, neural crest, presomitic mesoderm, and somites. In many cases, Frodo expression is confined to tissues undergoing extensive morphogenesis
frd1 is expressed in the developing brain and mesoderm.
two Dvl (显示 DVL2 蛋白)-associated paralogs, Dpr1 and Dpr2 (显示 DACT2 蛋白), participate in distinct Wnt (显示 WNT2 蛋白)-dependent developmental processes
target of beta-catenin (显示 CTNNB1 蛋白) and/or an unknown downstream effector in development
Findings suggest that the DACT1 c.1256G>A nonsense variant is causative of a specific genetic syndrome with features overlapping Townes-Brocks syndrome.
An inhibitory role for DACT1 in leukemogenesis.
Dact1 is up-regulated by TGF-beta1 (显示 TGFB1 蛋白), inducing apoptosis in mesangial cells.
The simultaneous methylation of DACT1 and DACT2 (显示 DACT2 蛋白) may play important roles in progression of ESCC and may serve as prognostic methylation biomarkers for ESCC patients.
Dact1 has a critical role in the ability support keratinocyte proliferation, by attenuating Wnt (显示 WNT2 蛋白)/beta catenin (显示 CTNNB1 蛋白) signaling.
our results suggested that DACT1 was upregulated during human placenta development.
There was no statistical difference between groups concerning DACT1 and DACT2 (显示 DACT2 蛋白) either in promoter hypermethylation or transcript levels. Age was associated with DACT2 (显示 DACT2 蛋白) promoter hypermethylation, especially over 56 years old.
Overexpression of Dapper-1 allows the translocation of MIZ-1 (显示 ZBTB17 蛋白) from the nucleus to the cytoplasm.
Dpr1 stabilizes the interaction between March2 and Dsh (显示 DVL2 蛋白) in order to mediate ubiquitylation and the subsequent degradation of Dsh (显示 DVL2 蛋白) protein only in the dorso-animal region of Xenopus embryo.
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene.
dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
, dapper 1
, dapper, antagonist of beta-catenin
, dapper, antagonist of beta-catenin, homolog 1
, dapper homolog 1-like
, dapper antagonist of catenin 1
, dapper homolog 1
, frodo homolog
, thymus expressed gene 3
, thymus-expressed novel gene 3 protein
, dishevelled-interacting protein
, frodo 1
, hepatocellular carcinoma novel gene 3 protein
, heptacellular carcinoma novel gene 3
, dapper 1-B
, dapper homolog 1, antagonist of beta-catenin