Use your antibodies-online credentials, if available.
frd1 is expressed in the developing brain and mesoderm.
two Dvl-associated paralogs, Dpr1 and Dpr2, participate in distinct Wnt-dependent developmental processes
target of beta-catenin and/or an unknown downstream effector in development
DACT1alpha plays a pivotal role as a potential tumor suppressor in migration and invasion of gastric cancer. DACT1alpha methylation may serve as a biomarker for the prognosis of gastric cancer.
Findings suggest that the DACT1 c.1256G>A nonsense variant is causative of a specific genetic syndrome with features overlapping Townes-Brocks syndrome.
Dapper1 attenuates hepatic gluconeogenesis and lipogenesis in Ttype 2 diabetes.
An inhibitory role for DACT1 in leukemogenesis.
Dact1 is up-regulated by TGF-beta1, inducing apoptosis in mesangial cells.
The simultaneous methylation of DACT1 and DACT2 may play important roles in progression of ESCC and may serve as prognostic methylation biomarkers for ESCC patients.
Dact1 has a critical role in the ability support keratinocyte proliferation, by attenuating Wnt/beta catenin signaling.
our results suggested that DACT1 was upregulated during human placenta development.
There was no statistical difference between groups concerning DACT1 and DACT2 either in promoter hypermethylation or transcript levels. Age was associated with DACT2 promoter hypermethylation, especially over 56 years old.
Dpr1 promotes the ubiquitination of Dvl2 by pVHL and mediates the protein aggregate-elicited autophagy initiation
Overexpression of Dapper-1 allows the translocation of MIZ-1 from the nucleus to the cytoplasm.
Dpr1 directly interacts with Beclin1 and Atg14L and enhances the Beclin1-Vps34 interaction and Vps34 activity.
Data indicate that Sestd1 cooperates with Dact1 in Vangl2 regulation and in the planar cell polarity (PCP) pathway during mammalian embryonic development.
five missense heterozygote mutations of the DACT1 gene are specifically identified in 167 stillborn or miscarried Han Chinese fetuses with neural tube defects.
These findings provided insight into the role of DACT1 as a novel functional tumor suppressor in gastric cancer through inhibiting NF-kappaB signaling pathway.
DACT1 stabilizes beta-catenin via DACT1-induced effects on GSK-3beta and directly interacts with beta-catenin proteins.
As(2)O(3) induces demethylation of hdpr1 gene from abnormal hypermethylation status and activates its reexpression, thus suppressing the proliferation of Jurkat cells.
Cytoplasmic HDPR1 protein expression was associated with tumor malignant progression via beta-catenin accumulation.
14-3-3beta interacts with human Dapper1, attenuating the ability of hDpr1 to promote Dishevelled (Dvl) degradation, thus enhancing Wnt signaling
Knockdown of HDPR1 gene enhanced the invasive ability of lung cancer cells, which was dependent on p120ctn and independent of beta-catenin
Dpr1 stabilizes the interaction between March2 and Dsh in order to mediate ubiquitylation and the subsequent degradation of Dsh protein only in the dorso-animal region of Xenopus embryo.
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene.
dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
, dapper 1
, dapper, antagonist of beta-catenin
, dapper, antagonist of beta-catenin, homolog 1
, dapper homolog 1-like
, dapper antagonist of catenin 1
, dapper homolog 1
, frodo homolog
, thymus expressed gene 3
, thymus-expressed novel gene 3 protein
, dishevelled-interacting protein
, frodo 1
, hepatocellular carcinoma novel gene 3 protein
, heptacellular carcinoma novel gene 3
, dapper 1-B
, dapper homolog 1, antagonist of beta-catenin