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EGLN3 抗体

(Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM2 in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurones, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation.
EGLN3 抗体  (AA 1-120) EGLN3 抗体  (AA 1-120) EGLN3 抗体 (AA 1-120) (ABIN6139990)

EGLN3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

EGLN3 抗体  (AA 1-239) EGLN3 抗体  (AA 1-239) EGLN3 抗体 (AA 1-239) (ABIN530188)

EGLN3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

EGLN3 抗体  (AA 1-120) EGLN3 抗体  (AA 1-120) EGLN3 抗体 (AA 1-120) (ABIN7151448)

EGLN3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

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Find EGLN3 抗体 for a variety of species such as anti-Human EGLN3, anti-Mouse EGLN3, anti-Rat EGLN3. The species listed below are among those available. Click on a link to go to the corresponding products.

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Popular EGLN3 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (6)
Cat. No. ABIN6139990
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (3)
Cat. No. ABIN530188
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7151448
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN7266910
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7177165
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN530189
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
  • (1)
Cat. No. ABIN530190
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IF
Validations
  • (1)
Cat. No. ABIN7264057
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN302149
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Pig, Rat
Application WB, IHC, IHC (p)
Validations
  • (1)
Cat. No. ABIN2599720
Quantity 50 μL
Datasheet Datasheet
Reactivity Chicken, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application WB, IHC, IHC (p)
Validations
  • (1)
Cat. No. ABIN6755451
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN5577119
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN5534232
Quantity 400 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
Cat. No. ABIN669741
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application ELISA
Validations
Cat. No. ABIN7177168
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our EGLN3 抗体

Pan, Strickland, Madhu, Johnson, Chand, Brody, Fertala, Zheng, Shapiro, Risbud: "RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells." in: Matrix biology : journal of the International Society for Matrix Biology, Vol. 77, pp. 23-40, (2019) (PubMed).

Miikkulainen, Högel, Seyednasrollah, Rantanen, Elo, Jaakkola: "Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma." in: The Journal of biological chemistry, Vol. 294, Issue 10, pp. 3760-3771, (2019) (PubMed).

Xu, Gao, Xue, Li, Xu, Li, Qin, Fang: "Prolyl hydroxylase 3 stabilizes the p53 tumor suppressor by inhibiting the p53-MDM2 interaction in a hydroxylase-independent manner." in: The Journal of biological chemistry, Vol. 294, Issue 25, pp. 9949-9958, (2019) (PubMed).

Bryant, Brown, Dobrikov, Dobrikova, Gemberling, Zhang, Gromeier: "Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2." in: Molecular and cellular biology, Vol. 38, Issue 11, (2018) (PubMed).

Sim, Cowburn, Palazon, Madhu, Tyrakis, Macías, Bargiela, Pietsch, Gralla, Evans, Kittipassorn, Chey, Branco, Rundqvist, Peet, Johnson: "The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia." in: Cell metabolism, Vol. 27, Issue 4, pp. 898-913.e7, (2018) (PubMed).

Egners, Rezaei, Kuzmanov, Poitz, Streichert, Müller-Reichert, Wielockx, Breier: "PHD3 Acts as Tumor Suppressor in Mouse Osteosarcoma and Influences Tumor Vascularization via PDGF-C Signaling." in: Cancers, Vol. 10, Issue 12, (2018) (PubMed).

Akat, Fıçıcılar, Durak, Tuncay, Dursun, Topal Çelikkan, Sabuncuoğlu, Turan, Baştuğ: "Intermittent hypoxia induces beneficial cardiovascular remodeling in left ventricular function of type 1 diabetic rat." in: Anatolian journal of cardiology, Vol. 19, Issue 4, pp. 259-266, (2018) (PubMed).

Chowdhury, Aich, Jain, Wozny, Lüchtenborg, Hartmann, Bernhard, Balleiniger, Alfar, Zieseniss, Toischer, Guan, Rizzoli, Brügger, Fischer, Katschinski, Rehling, Dudek: "Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia." in: Cell reports, Vol. 25, Issue 3, pp. 561-570.e6, (2018) (PubMed).

Yano, Sakai, Matsukawa, Yagi, Naganuma, Mitsushima, Iida, Inaba, Inoue, Unoki-Kubota, Kaburagi, Asahara, Kido, Minami, Kasuga, Matsumoto: "PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes." in: Scientific reports, Vol. 8, Issue 1, pp. 14290, (2018) (PubMed).

Bruno, Valerio, Casadei, De Nicola, Goeman, Pallocca, Catena, Iezzi, Sorino, Desantis, Manetti, Blandino, Floridi, Fanciulli: "Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization." in: Journal of experimental & clinical cancer research : CR, Vol. 36, Issue 1, pp. 32, (2017) (PubMed).

Aliases for EGLN3 抗体

egl-9 family hypoxia-inducible factor 3 (egln3) 抗体
egl-9 family hypoxia inducible factor 3 (EGLN3) 抗体
egl-9 family hypoxia-inducible factor 3 L homeolog (egln3.L) 抗体
egl-9 family hypoxia-inducible factor 3 (Egln3) 抗体
2610021G09Rik 抗体
AI505553 抗体
AI648162 抗体
EGLN3 抗体
Hif-p4h-3 抗体
HIFP4H3 抗体
HIFPH3 抗体
PHD-3 抗体
phd3 抗体
PHD3 抗体
Phd3 抗体
SM-20 抗体
wu:fj78a08 抗体
zgc:77019 抗体
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