anti-EGLN3 抗体

57 Egl Nine Homolog 3 (C. Elegans) (EGLN3) 抗体 from 11 manufacturers are available on www.antibodies-online.cn.

产品数据
  • 9
类型
  • 57
    Primary
抗原
  • 57
应用范围
  • 44
  • 35
  • 22
  • 6
  • 3
适用
  • 50
  • 14
  • 9
  • 3
  • 3
抗体来源
  • 44
  • 7
  • 6
克隆形成能力
  • 53
  • 4
克隆
  • 1
  • 1
  • 1
抗原表位
  • 10
  • 9
  • 7
  • 7
  • 4
标记
  • 28
  • 5
  • 5
  • 4
  • 3
抗体亚型
  • 31
  • 2
  • 1
  • 1
  • 1
Format
  • 43
  • 3
Suggested next Filters
57 产品
适用
应用范围 IF, WB
订购详情 分类号码 ABIN530188
$440.00
50 μg
加上运输费 $45.00
11至12个工作日
适用
应用范围 ELISA, WB
订购详情 分类号码 ABIN302149
$429.87
100 μg
加上运输费 $45.00
6至7个工作日
适用人, 小鼠, 大鼠
应用范围 WB
订购详情 分类号码 ABIN631137
$517.86
50 μg
加上运输费 $45.00
9至11个工作日
适用
应用范围 IHC (p), WB
订购详情 分类号码 ABIN5534232
$550.00
400 μL
加上运输费 $45.00
2至3个工作日
适用
应用范围 WB
订购详情 分类号码 ABIN6139990
$393.25
加上运输费 $45.00
13至14个工作日
适用
应用范围 IHC, ELISA, WB
订购详情 分类号码 ABIN2139718
$510.36
50 μL
加上运输费 $45.00
9至11个工作日
适用Cow, 犬, 豚鼠, 马, 人, 小鼠, 兔, 大鼠, 绵羊, 斑马鱼
应用范围 WB
订购详情 分类号码 ABIN2784911
$229.00
100 μL
加上运输费 $45.00
2至3个工作日
适用
应用范围 WB
订购详情 分类号码 ABIN530189
$425.71
100 μg
加上运输费 $45.00
11至12个工作日
适用
应用范围 ELISA
订购详情 分类号码 ABIN530190
$440.00
100 μg
加上运输费 $45.00
11至12个工作日
适用人, Pig, 大鼠
应用范围 IHC, IHC (p), WB
订购详情 分类号码 ABIN2599720
$639.83
50 μL
加上运输费 $45.00
11至14个工作日
适用小鸡, Cow, 犬, 豚鼠, 马, 人, 猴, 小鼠, Pig, 兔, 大鼠
应用范围 IHC, IHC (p), WB
订购详情 分类号码 ABIN6755451
$727.83
100 μL
加上运输费 $45.00
11至14个工作日
适用人, 小鼠, 大鼠
应用范围 IF (p), IHC (p), WB
订购详情 分类号码 ABIN669741
$327.80
100 μL
加上运输费 $45.00
3至7个工作日
适用小鼠
应用范围 ELISA, WB
订购详情 分类号码 ABIN1992143
$328.90
加上运输费 $45.00
13至16个工作日
适用小鼠
应用范围 ELISA, WB
订购详情 分类号码 ABIN1992141
$328.90
加上运输费 $45.00
13至16个工作日
适用小鼠
应用范围 ELISA, WB
订购详情 分类号码 ABIN1992142
$328.90
加上运输费 $45.00
13至16个工作日
  • <
  • 1

EGLN3 抗原简介

蛋白简介

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM2 in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurones, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation.

Alternative names and synonyms associated with EGLN3

  • egl-9 family hypoxia-inducible factor 3 (egln3) 抗体
  • egl-9 family hypoxia inducible factor 3 (EGLN3) 抗体
  • egl-9 family hypoxia-inducible factor 3 L homeolog (egln3.L) 抗体
  • egl-9 family hypoxia-inducible factor 3 (Egln3) 抗体
  • 2610021G09Rik 抗体
  • AI505553 抗体
  • AI648162 抗体
  • EGLN3 抗体
  • Hif-p4h-3 抗体
  • HIFP4H3 抗体
  • HIFPH3 抗体
  • PHD-3 抗体
  • Phd3 抗体
  • SM-20 抗体
  • wu:fj78a08 抗体
  • zgc:77019 抗体

Protein level used designations for EGLN3

Hif-p4h-3 , egl nine homolog 3 , phd3 , egl nine homolog 3 (C. elegans) , HIF-PH3 , HIF-prolyl hydroxylase 3 , HPH-3 , egl nine homolog 3, mitochondrial , factor-responsive smooth muscle protein , hypoxia-inducible factor prolyl hydroxylase 3 , prolyl hydroxylase domain-containing protein 3 , HIF prolyl hydroxylase 3 , HPH-1 , egl nine-like protein 3 isoform

GENE ID SPECIES
406602 Danio rerio
100145602 Xenopus (Silurana) tropicalis
100354210 Oryctolagus cuniculus
452850 Pan troglodytes
480286 Canis lupus familiaris
100219039 Taeniopygia guttata
100127282 Xenopus laevis
54702 Rattus norvegicus
423316 Gallus gallus
535578 Bos taurus
112407 Mus musculus
112399 Homo sapiens