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Bcl-2 interacting killer (Bik) decreases airway epithelial hyperplasia via apoptosis mediated by calcium release from the endoplasmic reticulum (ER), but the mechanism is unclear. Here the authors show that Bik promotes Bak (显示 BAK1 蛋白) enrichment at the ER to tether mitochondria for efficient calcium transfer.
These studies suggest a link between Bik-mediated caspase (显示 CASP3 蛋白) activation and cleavage of viral proteins.
OPN (显示 SPP1 蛋白) induces oxidative stress via the involvement of mitochondria and NOX-4 (显示 NOX4 蛋白). It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK.
Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 (显示 SQSTM1 蛋白) converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis.
Src (显示 SRC 蛋白) tyrosine kinase (显示 TYRO3 蛋白) inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.
The Bik protein, even in combination with Noxa (显示 PMAIP1 蛋白), is not a potent suppressor of c-Myc (显示 MYC 蛋白)-driven tumourigenesis or critical for chemotherapeutic drug-induced killing of Myc (显示 MYC 蛋白)-driven tumours.
BIKDD, a constitutively active mutant form of proapoptotic gene, BIK, effectively induces apoptosis of breast cancer cells and synergizes with lapatinib.
Blk has been mapped to chromosome 15 and overexpressed in transitional B cells of A/WySnJ mice, which demonstrate a cell-autonomous defect leading to excessive apoptosis.
any function of Bik in programmed cell death and stress-induced apoptosis must overlap that of other BH3-only (显示 BBC3 蛋白) proteins
Data show that Bik and Bim (显示 BCL2L11 蛋白) share the role of eliminating supernumerary germ cells during the first wave of spermatogenesis, a process vital for normal testicular development.
Suggest complex mechanism of tumor promotion in Bik high breast tumors.
BIK significantly contributes to DNA damage-induced mitochondrial apoptosis in HCT-116 wt cells upstream of the second peak of ROS (显示 ROS1 蛋白) production, BAX (显示 BAX 蛋白) and BAK (显示 BAK1 蛋白) activation, cytochrome c (显示 CYCS 蛋白) release and caspase (显示 CASP3 蛋白) activation.
our data demonstrated that suppression of BIK in ER-positive MCF-7 cells prevents the cytotoxic effect of TAM (显示 CCNA1 蛋白) and favors a more aggressive phenotype, due to the molecular change of different pathways
HCV RNA replication and release were significantly suppressed in BIK-depleted cells and over-expression of the RNA-dependent RNA polymerase, NS5B, was able to induce BIK expression
BikDDA, a novel mutant of Bik, showed a prolonged half-life and enhanced pro-apoptotic ability in triple-negative breast cancer cells compared with BikDD.
Authors show that human herpesvirus 4 EBNA2 represses BIK in B-cell lymphoma-derived cell lines and that this host-virus interaction can inhibit the proapoptotic effect of transforming growth factor beta1.
Data suggest BIK expression in tumor cells is not subject to direct regulation by MAP kinase (显示 MAPK1 蛋白) signaling; BIK expression appears to be cell-cycle-dependent and increases in G1 cell-cycle arrest which results from inhibition of MAP kinase (显示 MAPK1 蛋白) signaling.
BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.
BCL2-interacting killer (apoptosis-inducing)
, BCL2-interacting killer
, apoptosis inducer NBK
, bcl-2-interacting killer
, bik-like killer protein
, apoptosis-inducing NBK