This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].
custom-made
PUF60
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
PUF60
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
Latest Publications for our Poly-U Binding Splicing Factor 60KDa 蛋白
Fiorentino, Presby, Baer, Petri, Rieger, Soloski, Rosen, Mammen, Christopher-Stine, Casciola-Rosen: "PUF60: a prominent new target of the autoimmune response in dermatomyositis and Sjögren's syndrome." in: Annals of the rheumatic diseases, Vol. 75, Issue 6, pp. 1145-51, (2016) (PubMed).
Aliases for Poly-U Binding Splicing Factor 60KDa 蛋白