The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
Latest Publications for our Poliovirus Receptor 蛋白
Chandramohan, Bryant, Piao, Keir, Lipp, Lefaivre, Perkinson, Bigner, Gromeier, McLendon: "Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas." in: Archives of pathology & laboratory medicine, Vol. 141, Issue 12, pp. 1697-1704, (2017) (PubMed).
Hou, Ge, Zheng, Wei, Sun, Tian: "CD226 protein is involved in immune synapse formation and triggers Natural Killer (NK) cell activation via its first extracellular domain." in: The Journal of biological chemistry, Vol. 289, Issue 10, pp. 6969-77, (2014) (PubMed).
Chan, Martinet, Gilfillan, Souza-Fonseca-Guimaraes, Chow, Town, Ritchie, Colonna, Andrews, Smyth: "The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions." in: Nature immunology, Vol. 15, Issue 5, pp. 431-8, (2014) (PubMed).