Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for upf1/rent1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity).
Graber, Freemantle, Anadolu, Hébert-Seropian, MacAdam, Shin, Hoang, Alain, Lacaille, Sossin: "UPF1 Governs Synaptic Plasticity through Association with a STAU2 RNA Granule." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 37, Issue 38, pp. 9116-9131, (2017) (PubMed).