(Pleckstrin Homology Domain Containing, Family F (With FYVE Domain) Member 1 (PLEKHF1))
May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity).
Matsuda-Lennikov, Suizu, Hirata, Hashimoto, Kimura, Nagamine, Fujioka, Ohba, Iwanaga, Noguchi: "Lysosomal interaction of Akt with Phafin2: a critical step in the induction of autophagy." in: PLoS ONE, Vol. 9, Issue 1, pp. e79795, (2014) (PubMed).
Aliases for PLEKHF1 抗体
pleckstrin homology domain containing, family F (with FYVE domain) member 1 (plekhf1) 抗体 pleckstrin homology and FYVE domain containing 1 (PLEKHF1) 抗体 pleckstrin homology and FYVE domain containing 1 (plekhf1) 抗体 pleckstrin homology domain containing, family F (with FYVE domain) member 1 (Plekhf1) 抗体 pleckstrin homology and FYVE domain containing 1 (Plekhf1) 抗体 1810013P09Rik 抗体 APPD 抗体 LAPF 抗体 PHAFIN1 抗体 PLEKHF1 抗体 ZFYVE15 抗体 zgc:63897 抗体