This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Kiuru, Kurban, Itoh, Petukhova, Shimomura, Wajid, Christiano: "Hereditary leukonychia, or porcelain nails, resulting from mutations in PLCD1." in: American journal of human genetics, Vol. 88, Issue 6, pp. 839-44, (2011) (PubMed).