PLAUR 抗体
(Plasminogen Activator, Urokinase Receptor (PLAUR))
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008].
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Latest Publications for our PLAUR 抗体
: "uPAR isoform 2 forms a dimer and induces severe kidney disease in mice." in: The Journal of clinical investigation, Vol. 130, (2019) (PubMed).
: "Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease." in: Nature medicine, Vol. 23, Issue 1, pp. 100-106, (2017) (PubMed).
: "Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion." in: BMC cancer, Vol. 17, Issue 1, pp. 350, (2017) (PubMed).
: "Urokinase-type Plasminogen Activator (uPA) Binding to the uPA Receptor (uPAR) Promotes Axonal Regeneration in the Central Nervous System." in: The Journal of biological chemistry, Vol. 292, Issue 7, pp. 2741-2753, (2017) (PubMed).
: "Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. ..." in: Nature communications, Vol. 7, pp. 11626, (2016) (PubMed).
: "Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes." in: PLoS ONE, Vol. 9, Issue 8, pp. e105929, (2015) (PubMed).
: "A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease." in: Kidney international, Vol. 87, Issue 3, pp. 564-74, (2015) (PubMed).
: "Antipermeability function of PEDF involves blockade of the MAP kinase/GSK/beta-catenin signaling pathway and uPAR expression." in: Investigative ophthalmology & visual science, Vol. 51, Issue 6, pp. 3273-80, (2010) (PubMed).
: "Myxoma viral serpin, Serp-1, inhibits human monocyte adhesion through regulation of actin-binding protein filamin B." in: Journal of leukocyte biology, Vol. 85, Issue 3, pp. 418-26, (2009) (PubMed).
: "Urokinase plasminogen activator receptor-deficient mice demonstrate reduced hyperoxia-induced lung injury." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2182-9, (2009) (PubMed).
: "Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease." in: Nature medicine, Vol. 23, Issue 1, pp. 100-106, (2017) (PubMed).
: "Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion." in: BMC cancer, Vol. 17, Issue 1, pp. 350, (2017) (PubMed).
: "Urokinase-type Plasminogen Activator (uPA) Binding to the uPA Receptor (uPAR) Promotes Axonal Regeneration in the Central Nervous System." in: The Journal of biological chemistry, Vol. 292, Issue 7, pp. 2741-2753, (2017) (PubMed).
: "Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. ..." in: Nature communications, Vol. 7, pp. 11626, (2016) (PubMed).
: "Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes." in: PLoS ONE, Vol. 9, Issue 8, pp. e105929, (2015) (PubMed).
: "A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease." in: Kidney international, Vol. 87, Issue 3, pp. 564-74, (2015) (PubMed).
: "Antipermeability function of PEDF involves blockade of the MAP kinase/GSK/beta-catenin signaling pathway and uPAR expression." in: Investigative ophthalmology & visual science, Vol. 51, Issue 6, pp. 3273-80, (2010) (PubMed).
: "Myxoma viral serpin, Serp-1, inhibits human monocyte adhesion through regulation of actin-binding protein filamin B." in: Journal of leukocyte biology, Vol. 85, Issue 3, pp. 418-26, (2009) (PubMed).
: "Urokinase plasminogen activator receptor-deficient mice demonstrate reduced hyperoxia-induced lung injury." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2182-9, (2009) (PubMed).
Aliases for PLAUR 抗体
plasminogen activator, urokinase receptor (Plaur) 抗体plasminogen activator, urokinase receptor (PLAUR) 抗体
Cd87 抗体
CD87 抗体
Par 抗体
PLAUR 抗体
Plaur3 抗体
u-PAR 抗体
U-PAR 抗体
uPAR 抗体
UPAR 抗体
uPAR-2 抗体
uPAR-3 抗体
URKR 抗体
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