Plasmin 蛋白
(Plasmin/fibrinolysin (PL/Fbn))
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009].
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Latest Publications for our Plasmin 蛋白
: "Effects of extracellular DNA on plasminogen activation and fibrinolysis." in: The Journal of biological chemistry, Vol. 286, Issue 49, pp. 41949-62, (2011) (PubMed).: "Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator." in: Blood, Vol. 112, Issue 13, pp. 5046-51, (2008) (PubMed).
: "Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 17, pp. 6735-40, (2006) (PubMed).
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