This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
Loffredo, Borriello, Iannone, Ferrara, Galdiero, Gigantino, Esposito, Varricchi, Lambeau, Cassatella, Granata, Marone: "Group V Secreted Phospholipase A2 Induces the Release of Proangiogenic and Antiangiogenic Factors by Human Neutrophils." in: Frontiers in immunology, Vol. 8, pp. 443, (2017) (PubMed).
Yamaguchi, Zacharia, Laidlaw, Balestrieri: "PLA2G5 regulates transglutaminase activity of human IL-4-activated M2 macrophages through PGE2 generation." in: Journal of leukocyte biology, Vol. 100, Issue 1, pp. 131-41, (2016) (PubMed).
Aliases for PLA2G5 抗体
phospholipase A2 group V (PLA2G5) 抗体 phospholipase A2, group V (Pla2g5) 抗体 FRFB 抗体 GV-PLA2 抗体 hVPLA(2) 抗体 PLA2 抗体 PLA2-10 抗体 sPLA2 抗体