PKC gamma 产品
(Protein Kinase C, gamma (PRKCG))
Categories
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008].
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Featured PKC gamma Categories
PKC gamma 抗体
High quality antibodies with extensive validation data.
PKC gamma ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PKC gamma 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PKC gamma 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN703285
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN562388
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (2)
Cat. No.
ABIN6257417
Quantity
100 μL
Datasheet
Datasheet
Recommended PKC gamma ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962223
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969722
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958929
Quantity
96 tests
Datasheet
Datasheet
Recommended PKC gamma 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7563505
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7554315
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509105
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PKC gamma Products
: "5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): showing a strategy of designing drug to block lung metastasis of tumors." in: Drug design, development and therapy, Vol. 10, pp. 711-21, (2016) (PubMed).: "Carbonic Anhydrase 8 Expression in Purkinje Cells Is Controlled by PKC? Activity and Regulates Purkinje Cell Dendritic Growth." in: Molecular neurobiology, (2015) (PubMed).
: "Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity." in: Journal of translational medicine, Vol. 12, pp. 236, (2015) (PubMed).
: "Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14." in: Neurobiology of disease, Vol. 70, pp. 1-11, (2014) (PubMed).
: "Protein kinase C gamma mutations in spinocerebellar ataxia 14 increase kinase activity and alter membrane targeting." in: Brain : a journal of neurology, Vol. 128, Issue Pt 2, pp. 436-42, (2005) (PubMed).
: "Isoform-specific phosphorylation of metabotropic glutamate receptor 5 by protein kinase C (PKC) blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKC." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 2254-61, (2004) (PubMed).
: "A Ras activation pathway dependent on Syk phosphorylation of protein kinase C." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 16, pp. 9470-5, (2003) (PubMed).
: "Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gamma." in: Archives of neurology, Vol. 60, Issue 12, pp. 1749-51, (2003) (PubMed).
: "Identification of a novel SCA14 mutation in a Dutch autosomal dominant cerebellar ataxia family." in: Neurology, Vol. 61, Issue 12, pp. 1760-5, (2003) (PubMed).
: "Protein kinase C gamma (PKC gamma): function of neuron specific isotype." in: Journal of biochemistry, Vol. 132, Issue 5, pp. 683-7, (2002) (PubMed).
Synonyms and alternative names related to PKC gamma
protein kinase C gamma (PRKCG), protein kinase C, gamma (Prkcg), protein kinase C gamma type (LOC484316), protein kinase C gamma (Prkcg), PKC, PKC-gamma, PKCC, Pkcc, PKCG, PKCgamma, PKCI, Prkc, Prkcc, PRKCG, RATPKCI, SCA14Protein level used designations for PKC gamma
- protein kinase C, gamma
- protein kinase C gamma type-like
- protein kinase C gamma type
- PKC-gamma
- protein kinase C type I (gamma type)
- PKC-delta
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