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抗Mouse (Murine) PPP2R4 抗体:
抗Human PPP2R4 抗体:
Human Monoclonal PPP2R4 Primary Antibody for ICC, FACS - ABIN969557
Yoon, Jun, Park, Jun Yoo, Moon, Soon Baik, Kim, Kim, Kim, Koh, Taek Lee, You: Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal. in Stem cells (Dayton, Ohio) 2010
Show all 2 Pubmed References
Human Polyclonal PPP2R4 Primary Antibody for ELISA, WB - ABIN4347103
Gushiken, Patel, Liu, Pradhan, Bergeron, Peng, Vijayan: Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling. in The Journal of biological chemistry 2008
Human Monoclonal PPP2R4 Primary Antibody for IP, WB - ABIN1042656
Fellner, Lackner, Hombauer, Piribauer, Mudrak, Zaragoza, Juno, Ogris: A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo. in Genes & development 2003
Evidence for PPP2R4 as a haploinsufficient tumor suppressor gene, defining a high-penetrance genetic mechanism for PP2A (显示 PPP2R2B 抗体) inhibition in human cancer.
data indicate that PTPalpha (显示 PTPRA 抗体) and FAK (显示 PTK2 抗体), which are enriched in FAs (显示 FAS 抗体), interact with IP3R1 (显示 ITPR1 抗体) at adjacent ER sites to spatially sequester IL-1 (显示 IL1A 抗体)-induced Ca(2 (显示 CA2 抗体)+) signalling
oocyte-specific deletion of Ppp2r1a (显示 PPP2R1A 抗体) led to severe female subfertility without affecting follicle survival, growth, and ovulation.
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
PP2A (显示 PPP2R2B 抗体) (Protein Phosphatase 2A(Twins)) counteracts Plk4 (显示 PLK4 抗体) autophosphorylation, thus stabilizing Plk4 (显示 PLK4 抗体) and promoting centriole duplication
PP2A (显示 PPP2R2B 抗体)-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha (显示 TFAP2A 抗体), CREB (显示 CREB1 抗体), ETS-1 (显示 ETS1 抗体), and SP-1 (显示 SP1 抗体)
Data show that DSB promote PP2A to associate with Ku 70 and Ku 86.
findings show that ectopic expression of the phosphotyrosyl phosphatase activator PTPA induces cell death in mammalian cells via a mechanism involving caspase-3 (显示 CASP3 抗体)-dependent apoptosis
oxidative stress regulates the phosphorylation status of nonribosomal rpS3 (显示 RPS3 抗体) by both activating PKCdelta (显示 PKCd 抗体) and blocking the PP2A (显示 PPP2R2B 抗体) interaction with rpS3 (显示 RPS3 抗体)
protein phosphatase 2A overexpression in NIH 3T3 cells
Isoliensinine suppresses NF-kappaB (显示 NFKB1 抗体) in hepatocellular carcinoma cells through impairing PP2A/I2PP2A (显示 SET 抗体) interaction and stimulating PP2A-dependent p65 (显示 GORASP1 抗体) dephosphorylation at Ser536
BIR (显示 KCNJ11 抗体) domain of XIAP (显示 XIAP 抗体) activated the protein phosphatase 2 (PP2A) activity by decreasing the phosphorylation of PP2A at Tyr307 in its catalytic subunit, PP2A-C. Such activated PP2A prevented the deviant phosphorylation and activation of MAPK (显示 MAPK1 抗体) kinases/MAPKs, their downstream effector c-Jun (显示 JUN 抗体); and in turn inhibiting transcription of c-Jun (显示 JUN 抗体)-regulated miR (显示 MLXIP 抗体)-200a
T-type channel signaling is redirected towards the activation of the kinase Akt1 (显示 AKT1 抗体), leading to increased expression of the anti-apoptotic protein survivin (显示 BIRC5 抗体), and a decrease in the pro-apoptotic mediator FoxO3A (显示 FOXO3 抗体). Finally, in iPAH cells, Akt1 (显示 AKT1 抗体) is no longer able to regulate caspase 9 (显示 CASP9 抗体) activation, whereas T-type channel overexpression reverses PP2A defect in iPAH cells but reinforces the deleterious effects of Akt1 (显示 AKT1 抗体) activation
The present results indicate that rs959627 predicts PPP2R2 B mRNA prefrontal expression in two independent post-mortem datasets as well as lateral prefrontal activity during working memory in healthy subjects and suggest that genetic modulation of signal transduction mediated by PP2A affects complex biological phenotypes of relevance for cognitive behavior.
the present study suggested that PP2A has an important role in regulating mast cell beta2-adrenoceptors
The results of this study demonstrated that HBx of hepatitis B virus impairs interferon (显示 IFNA 抗体) signaling via increased expression of SOCS3 (显示 SOCS3 抗体) and PP2A.
The current study describes a novel pathogenic mechanism of action for human polyomavirus 6 small tumor (sT) antigen which involves binding to protein phosphatase 2A (PP2A) via its WFG motif and zinc binding sites for activation of PP2A's downstream oncogenic pathways (MEK (显示 MAP2K1 抗体)/ERK (显示 EPHB2 抗体)/c-Jun (显示 JUN 抗体)).
The aim of this review is to shed light on the role of four different phosphatases (PTEN (显示 PTEN 抗体), PP2A, CDC25 (显示 RASGRF1 抗体) and DUSP1 (显示 DUSP1 抗体)) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
Oncoprotein CIP2A (显示 KIAA1524 抗体) is stabilized via interaction with tumor suppressor PP2A/B56
Such effect by miR (显示 MLXIP 抗体)-429 was again abolished with AMPKalpha1 (显示 PRKAA1 抗体) silence or mutation. Together, we propose that PP2A-c silence by miR (显示 MLXIP 抗体)-429 activates AMPK (显示 PRKAA1 抗体) and protects osteoblastic cells from Dex.
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
PP2A subunit A isoform PR65-alpha
, PP2A subunit A isoform R1-alpha
, protein phosphatase PP2A
, serine/threonine protein phosphatase A subunit type 2A
, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
, PP2A phosphatase activator
, PP2A subunit B' isoform PR53
, phosphotyrosyl phosphatase activator
, protein phosphatase 2A, regulatory subunit B' (PR 53)
, serine/threonine-protein phosphatase 2A activator
, serine/threonine-protein phosphatase 2A regulatory subunit B'
, PP2A, subunit B', PR53 isoform
, serine/threonine-protein phosphatase 2A regulatory subunit 4
, protein tyrosine phosphatase, receptor type, A