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Studied role of MEK partner-1 (LAMTOR3) in driving MEK (显示 MAP2K1 抗体)/ERK (显示 EPHB2 抗体) pathway in EGFRviii-expressing glioma cells.
BCL2 (显示 BCL2 抗体) expression in mesennchymal lung cancer cells was induced by ERK1 (显示 MAPK3 抗体) activity through the upregulation of the MEK1 (显示 MAP2K1 抗体)/ERK1 (显示 MAPK3 抗体) scaffold protein (显示 HOMER1 抗体) MEK partner-1. Interfering with the MEK1 (显示 MAP2K1 抗体)/MP1 (显示 PITRM1 抗体)/ERK1 (显示 MAPK3 抗体) axis using a MEK1 (显示 MAP2K1 抗体) inhibitor or MP1 (显示 PITRM1 抗体) depletion repressed BCL2 (显示 BCL2 抗体) expression and sensitized MLCCs to chemoradiotherapy.
The present study was aimed at investigating whether the miR (显示 MLXIP 抗体)-29c binding site single nucleotide polymorphisms within the 3'-UTRs of LAMTOR3 gene affected the gastric cancer risk.
we demonstrate that the MAPK (显示 MAPK1 抗体) scaffold protein (显示 HOMER1 抗体) MEK partner 1 (MP1) is important for gastrin (显示 GAST 抗体)-induced phosphorylation of ERK1 (显示 MAPK3 抗体) and ERK2 (显示 MAPK1 抗体) and that MP1 (显示 PITRM1 抗体) promotes gastrin (显示 GAST 抗体)-induced proliferation of AGS (显示 JAG1 抗体)-GR cells
identified polymorphisms in LAMTOR2 (显示 LAMTOR2 抗体) and LAMTOR3 do not seem to play a relevant role in breast cancer
A complex encoded by the MAPKSP1, ROBLD3 (显示 LAMTOR2 抗体), and c11orf59 (显示 LAMTOR1 抗体) genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation
We investigated the neuroprotective effect of glial-derived neurotrophic factor (GDNF) upon alcohol-exposed B92 cultures, as well as the role of the cytoskeleton and mitogen-activated protein kinase (显示 MAPK1 抗体) (MAPK (显示 MAPK1 抗体)) pathways in this effect.
This novel mechanism for localization of intracellular Leishmania amazonensis-mediated ERK1/2 phosphorylation required the endosomal scaffold protein MP1 and localized to Leishmania amazonensis parasitophorous vacuoles.
We show an essential function for late endosomes carrying the p14 (显示 PCOLCE 抗体)-MP1 (LAMTOR2 (显示 LAMTOR2 抗体)/3) complex in focal adhesion dynamics.
Data indicate that LAMTOR3 protein is stabilized by associating with LAMTOR2 (显示 LAMTOR2 抗体).
A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation.
MP1 and the MP1*P14 complex have the potential to differentially modulate activating and inhibiting signals in the Raf-MKK1/2-ERK1/2 pathway.
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13.
MAPK scaffold protein 1
, mitogen-activated protein kinase kinase 1 interacting protein 1
, MEK binding partner 1
, late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
, mitogen-activated protein kinase scaffold protein 1
, ragulator complex protein LAMTOR3
, MEK-binding partner 1
, mitogen activated protein, binding protein
, mitogen-activated protein kinase kinase 1-interacting protein 1
, MEK partner 1
, Mitogen-activated protein kinase kinase 1-interacting protein 1
, Mitogen-activated protein kinase scaffold protein 1
, putative mitogen-activated protein kinase kinase 1 interacting protein 1