抗Human FOXO1 抗体:
抗Rat (Rattus) FOXO1 抗体:
抗Mouse (Murine) FOXO1 抗体:
Human Polyclonal FOXO1 Primary Antibody for ICC, IF - ABIN250693
Hoekstra, Sefton, Berry, Lu, Hardt, Marsh, Yin, Clardy, Chakravarti, Bulun, Kim: Progestins activate the AKT pathway in leiomyoma cells and promote survival. in The Journal of clinical endocrinology and metabolism 2009
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Human Polyclonal FOXO1 Primary Antibody for IHC (p), WB - ABIN546255
Gan, Zheng, Chabot, Unterman, Quirion: Nuclear/cytoplasmic shuttling of the transcription factor FoxO1 is regulated by neurotrophic factors. in Journal of neurochemistry 2005
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Human Polyclonal FOXO1 Primary Antibody for IHC - ABIN966149
Zhao, Gan, Pan, Kan, Majeski, Adam, Unterman: Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms. in The Biochemical journal 2004
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Human Polyclonal FOXO1 Primary Antibody for IF, IHC - ABIN362088
Zhan, Wang, Li, Xu, Sun, Xu: Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre-conditioning in adult rats. in Journal of neurochemistry 2010
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Human Polyclonal FOXO1 Primary Antibody for IHC (fro), IF - ABIN4948288
Sajan, Ivey, Lee, Mastorides, Jurczak, Samuels, Shulman, Braun, Leitges, Farese: PKC? haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. in Molecular endocrinology (Baltimore, Md.) 2014
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Human Polyclonal FOXO1 Primary Antibody for IHC (p), WB - ABIN546256
Rena, Prescott, Guo, Cohen, Unterman: Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting. in The Biochemical journal 2001
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Human Polyclonal FOXO1 Primary Antibody for IF, IHC - ABIN6713306
Xiao, Moon, Yan, Nian, Zhang, Liu, Lu, Guan, Chen, Jiang, Jiang, Liu, Li: Cellular FLICE-inhibitory protein protects against cardiac remodelling after myocardial infarction. in Basic research in cardiology 2012
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Human Polyclonal FOXO1 Primary Antibody for IF, IHC - ABIN6714277
Wang, Gu, He, Ye, Chen, Zhang, Hai: Glucose oxidase induces insulin resistance via influencing multiple targets in vitro and in vivo: The central role of oxidative stress. in Biochimie 2012
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Human Polyclonal FOXO1 Primary Antibody for IHC - ABIN966148
Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. in The Journal of cell biology 2005
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Human Polyclonal FOXO1 Primary Antibody for ICC, IF - ABIN4312363
Sahu, Laakso, Ovaska, Mirtti, Lundin, Rannikko, Sankila, Turunen, Lundin, Konsti, Vesterinen, Nordling, Kallioniemi, Hautaniemi, Jänne: Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer. in The EMBO journal 2011
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Data show that menin stabilizes forkhead box O1 protein (FOXO1) by repressing FOXO1 degradation mediated by S-phase kinase-associated protein 2 (Skp2).
FOXO1 gene rs17446614 SNP, and the A-C haplotype of rs17446614 and rs17592236 polymorphisms were risk factors for the development of DN
FOXO1 activity is essential for growth and maintenance of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Genetic and pharmacological inactivation of FOXO1 in BCP-ALL cell lines produced a strong antileukemic effect associated with CCND3 downregulation.
Recurrent FOXO1 mutations, which prevent AKT targeting and lock the transcription factor in the nucleus, are used by BL to circumvent mutual exclusivity between PI3K and FOXO1 activation
EPS8L3 might promote proliferation by hyperactivating the AKT signaling pathway and subsequently inhibiting the FOXO1 transcriptional activity in hepatocellular carcinoma
we demonstrated that miR-27a promoted the progression of ovarian cancer cells and induced the process of EMT via the Wnt/beta-catenin signalling pathway through inhibition of FOXO1.
The upregulation of MCP1, phosphorylated forkhead boxO1 (pFOXO1), and phosphorylated mTOR (pmTOR) was observed in vivo and in vitro.
FOXO1 dysregulation plays an important role in infantile haemangiomas pathogenesis. FOXO1 expression was downregulated in IH tissue samples and ECs and was correlated with IH proliferation and involution.
Insulin suppression of gluconeogenic enzyme expression is facilitated by coordinated inactivation of FoxO1 and PGC-1alpha by WD40/ProF-associated Akt; but this coordination also increases vulnerability to aPKC hyperactivity, which is abetted by SREBP-1c-induced increases in PGC-1alpha and PKC-iota.
full basal FOXO1 transactivation activity relies on Cys612, which mediates synergistic effects of coregulators, CBP or PGC1alpha, on FOXO1 transcriptional activity
miR-486-5p may inhibit the proliferation of leukemia cells and induce apoptosis through targeting FOXO1.
genetic variant rs10823108 in SIRT1 and variant rs17446614 in FoxO1 may contribute to the risk of DN in T2DM patients.
we identified the transcription factor FoxO1 as a potential mediator of ERK2-induced EMT, and thus we investigated the mechanism by which ERK2 regulates FoxO1. Additionally, our analysis revealed that ERK2 induced the expression of Dock10, a Rac1/Cdc42 GEF, during EMT
miR-215 promotes cell migration and invasion of gastric cancer by targeting FOXO1.
these results provide a mechanism for how interdependent FoxO1:FoxA1/2 binding is negatively impacted by insulin and provide a developmental context for cooperative gene activation by these factors.
FOXO1 is involved in establishing endothelial tip cell polarity during sprouting angiogenesis. MST1 (Stk4) regulates FOXO1 localization at tip endothelial cells.
PAX3-FOXO1 regulates key microRNAs that may represent novel therapeutic vulnerabilities in fusion positive Rabdomyosarcomas.
miR-486-5p can inhibit inflammatory response, ECM degradation and apoptosis in NP cells by directly targeting FOXO1, which may contribute to the biological therapy of intervertebral disc degeneration.
Low FOXO1 expression is associated with cancer.
The reciprocal expression of PGR and FOXO1 was conserved in endometrial samples during the proliferative and secretory phase. Expression of FOXO1 and the loss of PGR during the window of receptivity are interrelated and critical for embryo implantation.
The findings reveal a novel mechanism by which Ca2+ overload disrupts myofibril integrity by activating a Calcineurin-FoxO-MuRF1-proteosome signaling pathway.
These results indicate that miR-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.
gas6 protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt-dependent inactivation of FOXO1a.
age-related muscle weight loss tended to be suppressed in the LC-Plasma group and expression of the muscle degeneration gene FoxO-1 was significantly suppressed. Related to these phenotypes, the senescence score in the LC-Plasma group was significantly decreased at 47weeks of age compared with that in the control group.
CK2 regulates the Th17/Treg axis through the inhibition of FoxO1.
further mechanism research indicated that sweroside could activate the SIRT1, then suppress the nuclear factor-kappa B (NF-kappaB) and promote the Forkhead transcription factor O1 (FOXO1) signaling pathways
this study demonstrates maintenance of CD4 T cell fitness through regulation of Foxo1
SIRT6 deficiency results in decreased oxygen consumption rate and concomitantly lesser ATP production. Mechanistically, SIRT6 deficiency leads to increased FoxO1-mediated transcription of PDK4. Our findings establish a novel link between SIRT6 and cardiac metabolism, suggesting a protective role of SIRT6 in maintaining cardiac homeostasis.
This work establishes a novel molecular mechanism of mood behavior regulation by leptin and suggests FoxO1 suppression by leptin might be a key for leptin-induced behavioral manifestation
FOXO1 deletion in keratinocytes improves re-epithelialization of diabetic wound via MMP9 regulation.
These results indicate that liver FoxO1 promotes serpinB1 expression in hepatic insulin resistance and that non-cell-autonomous factors contribute to FoxO1-dependent effects on serpinB1 expression in the liver.
FOXO1 is continuously required for all the phenotypic characteristics of memory-effector T cells such that with acute inactivation of the gene encoding FOXO1, T cells revert to a short-lived effector phenotype, exhibit reduced viability, and manifest characteristics of anergy.
FOXO1 s involved in establishing endothelial tip cell polarity during sprouting angiogenesis.MST1 regulates FOXO1 localization at tip endothelial cells.
the CAR-Akt-Foxo1 signalling pathway has an essential role in controlling hepatocyte proliferation by repressing the cell cycle regulator Cdkn1a (p21)
these findings reveal the pivotal role of FoxO1 in controlling endothelial metabolic and angiogenic adaptations in response to high-fat diet.
Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention
Results demonstrate that the timing of FOXO1 activation affects its role in pituitary gland organogenesis and somatotrope differentiation.
High Foxo1 expression is associated with cardiac dysfunction.
Demonstrate that the transcription factor Forkhead Box O1 (FOXO1) is a critical regulator of endometrial receptivity in vivo. Uterine ablation of Foxo1 using the progesterone receptor Cre (PgrCre) model resulted in infertility due to altered epithelial cell polarity and apoptosis, preventing the embryo from penetrating the luminal epithelium.
The results together illustrated that as a major regulator in redox homeostasis and osteoblast physiology, FoxO1 provides a favorable intracellular environment for osteoblast functions by defensing against the adverse effects of oxidative stress.
FOXO1-suppressed miR-424 regulates both the proliferation and osteogenic differentiation of mesenchymal stem cells via targeting FGF2.
Studied the effects of microRNA-27a on myogenin expression and the Akt/FoxO1 signal pathway during porcine myoblast differentiation. Overexpression of miR-27a suppressed myogenin expression during porcine myoblast differentiation, whereas inhibition of miR-27a promoted the mRNA and protein expression levels of myogenin; overexpression of miR-27a decreased the level of P-Akt/Akt and increased the protein level of FoxO1.
he knockdown of FoxO1 repressed lipogenesis by downregulating PDGFRalpha, and miR-34a inhibited adipogenesis through targeting PDGFRalpha.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.
let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.
inhibition of FoxO1 expression level caused by miR-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1
Results show that FoxO1 likely regulates MyHC I negatively and MyHC IIx and MyHC IIb positively and may play a pivotal role in the determination of muscle fiber type.
Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL expression during follicular atresia.
Data show that IL-4 induces upregulation of the junction protein claudin-5 in endothelial cells (ECs) through activation of Jak/STAT6 and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.
FoxO1 and C/EBPb regulate preadipocyte adipogenesis possibly through C/EBPb-> FoxO1-> C/EBPb feedback regulatory loop and FoxO1-C/EBPb protein complex.
FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.
concluded that PI 3-kinase and Akt are activated after renal ischemia/reperfusion and that Akt phosphorylation leads to phosphorylation of FKHR and FKHRL1, which may affect epithelial cell fate in acute renal failure.
FoxO1a can regulate p27kip nuclear localization
FoxO1 expression level has a negative correlation with the development of muscle fiber
results suggested that porcine FoxO1 gene took part in the regulation of adipose and was a negative transcription regulation factor in preadipocyte differentiation
This is the first study demonstrating a role for AMPK-SIRT1-FOXO1 signalling pathway in regulating apoptosis in bovine intramuscular adipocytes.
MicroRNA-183-96-182 cluster regulates bovine granulosa cell function by targeting FOXO1 gene.
downregulation of SIRT1 and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age
Animals with genotype AA at SNP A176183G in FOX01 had significantly greater body length, chest breadth and chest depth than those with genotypes AG and GG.
FOXO is a key regulator of ROS-induced apoptosis in mammalian cells.
Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule-1 mRNA.
The results demonstrate pathways through which two different mediators, TNF-alpha and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.
FOXO1, 3, and 4 as well as their upstream regulator, AKT/p-AKT, was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult
FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase and catalase mRNA and protein levels in this organ.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
forkhead box protein O1
, forkhead box protein O1A
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma
, forkhead box O1A
, forkhead box protein O1-A
, fox family transcription factor FoxO1a.1
, foxhead box protein O1-A
, Forkhead box protein O1A
, Forkhead in rhabdomyosarcoma
, forkhead box O1A (rhabdomyosarcoma)
, forkhead box O1a
, forkhead in rhabdomyosarcoma
, forkhead protein 1
, forkhead/winged helix transcription factor FOXO1a
, forkhead box O1
, forkhead box protein O1-like