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抗Human FOXO1 抗体:
抗Rat (Rattus) FOXO1 抗体:
抗Mouse (Murine) FOXO1 抗体:
Human Polyclonal FOXO1 Primary Antibody for ICC, IF - ABIN250693
Hoekstra, Sefton, Berry, Lu, Hardt, Marsh, Yin, Clardy, Chakravarti, Bulun, Kim: Progestins activate the AKT pathway in leiomyoma cells and promote survival. in The Journal of clinical endocrinology and metabolism 2009
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Human Polyclonal FOXO1 Primary Antibody for IHC - ABIN966149
Zhao, Gan, Pan, Kan, Majeski, Adam, Unterman: Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms. in The Biochemical journal 2004
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Human Polyclonal FOXO1 Primary Antibody for IF, IHC - ABIN362088
Zhan, Wang, Li, Xu, Sun, Xu: Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre-conditioning in adult rats. in Journal of neurochemistry 2010
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Human Polyclonal FOXO1 Primary Antibody for IHC (fro), IF - ABIN4948288
Sajan, Ivey, Lee, Mastorides, Jurczak, Samuels, Shulman, Braun, Leitges, Farese: PKC? haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. in Molecular endocrinology (Baltimore, Md.) 2014
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Human Polyclonal FOXO1 Primary Antibody for IHC - ABIN966148
Gan, Zheng, Chabot, Unterman, Quirion: Nuclear/cytoplasmic shuttling of the transcription factor FoxO1 is regulated by neurotrophic factors. in Journal of neurochemistry 2005
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Human Monoclonal FOXO1 Primary Antibody for ICC, IHC - ABIN969521
Lau, Koty, Nalbantoglu: Differential response of glioma cells to FOXO1-directed therapy. in Cancer research 2009
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Human Polyclonal FOXO1 Primary Antibody for ICC, IF - ABIN4312363
Sahu, Laakso, Ovaska, Mirtti, Lundin, Rannikko, Sankila, Turunen, Lundin, Konsti, Vesterinen, Nordling, Kallioniemi, Hautaniemi, Jänne: Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer. in The EMBO journal 2011
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Human FOXO1 Primary Antibody for IHC - ABIN966146
Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. in The Journal of cell biology 2005
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Human Polyclonal FOXO1 Primary Antibody for IF (p), IHC (p) - ABIN684748
Li, Qiu, Liu, Wang, Hu, Gan, Wang: Long-term thermal manipulation in the late incubation period can inhibit breast muscle development by activating endoplasmic reticulum stress in duck (Anasplatyrhynchos domestica). in Journal of thermal biology 2017
Human Polyclonal FOXO1 Primary Antibody for IF (p), IHC (p) - ABIN684733
Lowther, Goods, Lucca, Lerner, Raddassi, van Dijk, Hernandez, Duan, Gunel, Coric, Krishnaswamy, Love, Hafler: PD-1 marks dysfunctional regulatory T cells in malignant gliomas. in JCI insight 2016
This study is the first to demonstrate FOXO1 gene rearrangements in malignant ectomesenchymoma with alveolar rhabdomyosarcoma subtype.
The HIF1alphainduced expression of Runx2 (显示 RUNX2 抗体) and ALP (显示 ALP 抗体) may be completely dependent on the expression levels of Foxo1, and in turn, osteocalcin (显示 BGLAP 抗体) may be partially dependent on Foxo1 expression.
A novel role of FoxO1 inhibition in promoting IPC differentiation of hESCs.
FOXO1 overexpression increased the length of the microvilli on the cell surface, whereas FOXO1 silencing significantly reduced their length.
High FOXO1 expression is associated with prostatic cancer.
FOXO1 serves as an important linker between HER2 (显示 ERBB2 抗体) and MET signaling pathways through negative crosstalks and is a key regulator of the acquired lapatinib resistance in HER2 (显示 ERBB2 抗体)-positive GC cells.
LncRNA DANCR could inhibit osteoblast differentiation by regulating FOXO1 expression.
A significant correlation between the physical activity level and peripheral blood mononuclear cell SIRT1 (显示 SIRT1 抗体) and FOXO1 mRNA expression was found in COPD (显示 ARCN1 抗体) patients.
results indicate that FOXO1 inhibits gastric cancer (GC) growth and angiogenesis under hypoxic conditions via inactivation of the HIF-1alpha (显示 HIF1A 抗体)-VEGF (显示 VEGFA 抗体) pathway, possibly in association with SIRT1 (显示 SIRT1 抗体); thus, development of treatment modalities aiming at this pathway might be useful for treating GC
These results suggest that liraglutide may exert a renoprotective effect by a FoxO1-mediated upregulation of renal MnSOD (显示 SOD2 抗体) expression in the early DKD.
The findings reveal a novel mechanism by which Ca2 (显示 CA2 抗体)+ overload disrupts myofibril integrity by activating a Calcineurin-FoxO (显示 FOXO3 抗体)-MuRF1 (显示 TRIM63 抗体)-proteosome signaling pathway.
These results indicate that miR (显示 MYLIP 抗体)-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.
gas6 (显示 GAS6 抗体) protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt (显示 AKT1 抗体)-dependent inactivation of FOXO1a.
the results of the present study suggest that moderate overexpression of SIRT1 (~3fold of normal level) may directly or indirectly inhibit apoptosis of OBs via the FOXO1 and betacatenin signaling pathway.
insulin (显示 INS 抗体)-activated SREBP1c (显示 SREBF1 抗体) downregulates gluconeogenesis through CRY1 (显示 CRY1 抗体)-mediated FOXO1 degradation.
Our study demonstrated that Arachidonic acid (AA) inhibits macrophage viability by inducing S phase cell cycle arrest. The JNK (显示 MAPK8 抗体) signaling pathway and the downstream FoxO (显示 FOXO3 抗体) transcription factors are involved in AA-induced RAW264.7 cell cycle arrest.
the transcription of Rho-associated coiled-coil containing protein kinase 1 (ROCK1 (显示 ROCK1 抗体)), which phosphorylates Drp1 (显示 CRMP1 抗体) at Ser616, was shown by luciferase assay to be directly regulated by FOXO1. These findings suggested that FOXO1 is critical to preserve mitochondrial quantity and function in ECs, and FOXO1 may serve as a therapeutic target for microvascular complications of diabetes.
Chimeric antigen receptor T cells releasing IL-18 (显示 IL18 抗体) convert to T-Bet(high) FoxO1(low) effectors that exhibit augmented activity against advanced solid tumors.
the molecular level, we confirmed, for the first time, that RES upregulated FoxO1 transcriptional activity by inhibiting the PI3K/AKT (显示 AKT1 抗体) signaling pathway, and hence promoted resistance to oxidative damage and restrained osteoclastogenesis. Inhibition of the PI3K/AKT (显示 AKT1 抗体) signaling pathway may be induced by RANKL (显示 TNFSF11 抗体).
FOXO1 is dispensable for naive T cell expression of TCF7 (显示 TCF7 抗体), it is essential for the expression of TCF7 (显示 TCF7 抗体) in a small subset of T cells within days following primary infection.
Foxo1 expression compromised embryonic stem cell self-renewal
we identified that Sirtuin 1 (SIRT1 (显示 SIRT1 抗体)), a deacetylase that suppresses FoxO1 acetylation in granulosa cell (GCs (显示 UGCG 抗体)), was downregulated by miR (显示 MLXIP 抗体)-181a and reversed the promoting effects of H2O2 and miR (显示 MLXIP 抗体)-181a on FoxO1 acetylation and GC apoptosis.
Study identified the roles of Foxo1 as a positive regulator and Foxp1 as a negative regulator of TH9 cell differentiation and antitumor activity.
Studied the effects of microRNA-27a on myogenin (显示 MYOG 抗体) expression and the Akt (显示 AKT1 抗体)/FoxO1 signal pathway during porcine myoblast differentiation. Overexpression of miR (显示 MYLIP 抗体)-27a suppressed myogenin (显示 MYOG 抗体) expression during porcine myoblast differentiation, whereas inhibition of miR (显示 MYLIP 抗体)-27a promoted the mRNA and protein expression levels of myogenin (显示 MYOG 抗体); overexpression of miR (显示 MYLIP 抗体)-27a decreased the level of P-Akt/Akt (显示 AKT1 抗体) and increased the protein level of FoxO1.
he knockdown of FoxO1 repressed lipogenesis by downregulating PDGFRalpha, and miR (显示 MYLIP 抗体)-34a inhibited adipogenesis through targeting PDGFRalpha.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (显示 AKT1 抗体)-mTOR (显示 FRAP1 抗体)-FOXO1 signaling and suppressing the activation of TLR4 (显示 TLR4 抗体) and/or NOD2 (显示 NOD2 抗体) signaling pathways.
let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 (显示 MAP3K1 抗体) gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.
inhibition of FoxO1 expression level caused by miR (显示 MYLIP 抗体)-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR (显示 MYLIP 抗体)-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1
Results show that FoxO1 likely regulates MyHC I (显示 MYH7 抗体) negatively and MyHC IIx and MyHC IIb (显示 MYH4 抗体) positively and may play a pivotal role in the determination of muscle fiber type.
Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (显示 TNFSF10 抗体) and Fas ligand FasL (显示 FASL 抗体) expression during follicular atresia.
Data show that IL-4 (显示 IL4 抗体) induces upregulation of the junction protein claudin-5 (显示 CLDN5 抗体) in endothelial cells (ECs) through activation of Jak (显示 JAK3 抗体)/STAT6 (显示 STAT6 抗体) and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.
FoxO1 and C/EBPb (显示 CEBPB 抗体) regulate preadipocyte adipogenesis possibly through C/EBPb (显示 CEBPB 抗体)-> FoxO1-> C/EBPb (显示 CEBPB 抗体) feedback regulatory loop and FoxO1-C/EBPb (显示 CEBPB 抗体) protein complex.
FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.
This is the first study demonstrating a role for AMPK (显示 PRKAA1 抗体)-SIRT1 (显示 SIRT1 抗体)-FOXO1 signalling pathway in regulating apoptosis in bovine intramuscular adipocytes.
MicroRNA-183-96-182 cluster regulates bovine granulosa cell function by targeting FOXO1 gene.
downregulation of SIRT1 (显示 SIRT1 抗体) and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age
FOXO (显示 FOXO3 抗体) is a key regulator of ROS (显示 ROS1 抗体)-induced apoptosis in mammalian cells.
Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule (显示 NCAM1 抗体)-1 mRNA.
The results demonstrate pathways through which two different mediators, TNF-alpha (显示 TNF 抗体) and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.
FOXO1, 3, and 4 as well as their upstream regulator, AKT/p-AKT (显示 AKT1 抗体), was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult
FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase (显示 SOD1 抗体) and catalase (显示 CAT 抗体) mRNA and protein levels in this organ.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
forkhead box protein O1
, forkhead box protein O1A
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma
, forkhead box O1A
, forkhead box protein O1-A
, fox family transcription factor FoxO1a.1
, foxhead box protein O1-A
, Forkhead box protein O1A
, Forkhead in rhabdomyosarcoma
, forkhead box O1A (rhabdomyosarcoma)
, forkhead box O1a
, forkhead in rhabdomyosarcoma
, forkhead protein 1
, forkhead/winged helix transcription factor FOXO1a
, forkhead box O1
, forkhead box protein O1-like