anti-FOXO1 (FOXO1) 抗体产品概述

Human Forkhead Box O1 (FOXO1) interaction partners

1. the present study demonstrated that the expression of miR (显示 MLXIP 抗体)-196a in human liver cancer cells was upregulated; downregulation of miR (显示 MLXIP 抗体)-196a regulated human liver cancer cell biological functions which could benefit the clinical therapy of human liver cancer in the future

2. Inhibition of FOXO1 enhanced angiogenesis in human bio-engineered capillaries, and resulted in microvascular regeneration and improved function in mouse models of injury-repair.

3. Cells harboring the fusion gene are selectively sensitive to small-molecule inhibition of protein targets induced by, or bound to, PAX3 (显示 PAX3 抗体)-FOXO1-occupied super enhancers. Furthermore, PAX3 (显示 PAX3 抗体)-FOXO1 recruits and requires the BET bromodomain protein BRD4 (显示 BRD4 抗体) to function at super enhancers, resulting in a complete dependence on BRD4 (显示 BRD4 抗体) and a significant susceptibility to BRD inhibition

4. FOXO1 silencing also augmented the migratory behavior of SW-13 cells (p<0.0001), suggesting distinct roles for FOXO1 in promoting viability and controlled motility of adrenocortical cells.

5. the miRNA-223can maintain cell proliferation of breast cancer cell through targeting FOXO 1.

6. MEG3 (显示 FAM129B 抗体) acts as a ceRNA to regulate expression of E-cadherin (显示 CDH1 抗体) and FOXO1 by competitively binding miR (显示 MLXIP 抗体)-9 and may be used as a potential biomarker in predicting ESCC patients' progression and prognosis

7. These results strongly suggest that AMPK (显示 PRKAA1 抗体) can activate ORP150 (显示 HYOU1 抗体) through FOXO1 pathway and confer protection against endoplasmic reticulum stress - induced apoptosis of airway epithelial cells following exposure to cigarette smoke extract.

8. LAT1 (显示 LAT 抗体)-NAD+-SIRT1 (显示 SIRT1 抗体) signaling is activated in tumor tissues of patients with non-small cell lung cancer; NAD+ synthesis regulates the SIRT1 (显示 SIRT1 抗体)-FOXO1 apoptotic pathway in response to NQO1 (显示 NQO1 抗体)

9. Knockdown of FOXO4 (显示 FOXO4 抗体) but not FOXO1 expression decreased proteasome activity. Following neural differentiation, the HD-iPSC-derived neural progenitor cells (NPCs) demonstrated lower levels of proteasome activity and FOXO (显示 FOXO3 抗体) expressions than their WT counterparts. More importantly, overexpression of FOXO4 (显示 FOXO4 抗体) but not FOXO1 in HD NPCs dramatically enhanced proteasome activity.

10. The borders of this novel topologically associating domains (TADs)correspond to the original 5'- and 3'- borders of the PAX3 (显示 PAX3 抗体) and FOXO1 TADs, respectively, suggesting that TAD (显示 CRTAM 抗体) organisation precedes the formation of regulatory long-range interactions. Our results demonstrate that, upon translocation, novel regulatory landscapes are formed allowing new intra-TAD (显示 CRTAM 抗体) interactions between the original loci involved

Zebrafish Forkhead Box O1 (FOXO1) interaction partners

1. These results indicate that miR (显示 MYLIP 抗体)-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.

2. gas6 (显示 GAS6 抗体) protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt (显示 AKT1 抗体)-dependent inactivation of FOXO1a.

Mouse (Murine) Forkhead Box O1 (FOXO1) interaction partners

1. Inhibition of FOXO1 enhanced angiogenesis in human bio-engineered capillaries, and resulted in microvascular regeneration and improved function in mouse models of injury-repair.

2. Authors found that the repress effect of alphaMSH (显示 POMC 抗体) in adipocytes apoptosis is acting through Foxo1/mTORC2 (显示 CRTC2 抗体) pathway. These findings indicate that, alphaMSH (显示 POMC 抗体) has a strong inhibitory effect on ROS (显示 ROS1 抗体)-induced adipocyte apoptosis and underlying mechanism is interacting with key factors in mTOR (显示 FRAP1 抗体) signal pathway.

3. Sirt3 (显示 SIRT3 抗体) activation is essential to improve autophagy flux by reducing the acetylation modification on FoxO1, which in turn alleviates myocardial hypertrophy.

4. The data reveal a novel mechanism in which the elevated miR (显示 MLXIP 抗体)-425 in IBD mediates pathogenic Th17 cell generation through down-regulation of Foxo1.

5. we found that in db/db (显示 LEPR 抗体) VSMC, the occupancy in promoter regions of inflammatory genes by FOXO1 was reduced.miR-135a increased the inflammatory responses of VSMC involved in complications of vascular diseases by downregulating the expression of FOXO1.

6. Trehalose may rescue against insulin (显示 INS 抗体) resistance-induced myocardial contractile defect and apoptosis, via autophagy associated with dephosphorylation of p38 MAPK (显示 MAPK14 抗体) and Foxo1 without affecting phosphorylation of Akt (显示 AKT1 抗体).

7. FoxO1 is a key mediator involved in glucose homeostasis and indicate that 1,25(OH)2D3 improves glucose metabolism and bone development

8. Data show that the mitochondrial enriched GCN5 (显示 KAT2A 抗体)-like 1 protein (GCN5L1 (显示 BLOC1S1 抗体)) controls hepatic glucose production by regulating FoxO1 protein levels.

9. Setdb1 (显示 SETDB1 抗体) regulates PTEN/AKT (显示 AKT1 抗体)/FOXO1 pathway to inhibit Spermatogonial stem cells apoptosis.

10. These findings indicate that IGF-II reduces PGC-1alpha expression in skeletal muscle cells through a mechanism involving PI3K-Akt (显示 AKT1 抗体)-FoxO1 but not p38 MAPK (显示 MAPK14 抗体) or Erk1/2 MAPK (显示 MAPK1 抗体) pathways.

Pig (Porcine) Forkhead Box O1 (FOXO1) interaction partners

1. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (显示 AKT1 抗体)-mTOR (显示 FRAP1 抗体)-FOXO1 signaling and suppressing the activation of TLR4 (显示 TLR4 抗体) and/or NOD2 (显示 NOD2 抗体) signaling pathways.

2. let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 (显示 MAP3K1 抗体) gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.

3. inhibition of FoxO1 expression level caused by miR (显示 MYLIP 抗体)-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR (显示 MYLIP 抗体)-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1

4. Results show that FoxO1 likely regulates MyHC I (显示 MYH7 抗体) negatively and MyHC IIx and MyHC IIb (显示 MYH4 抗体) positively and may play a pivotal role in the determination of muscle fiber type.

5. Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (显示 TNFSF10 抗体) and Fas ligand FasL (显示 FASL 抗体) expression during follicular atresia.

6. Data show that IL-4 (显示 IL4 抗体) induces upregulation of the junction protein claudin-5 (显示 CLDN5 抗体) in endothelial cells (ECs) through activation of Jak (显示 JAK3 抗体)/STAT6 (显示 STAT6 抗体) and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.

7. FoxO1 and C/EBPb (显示 CEBPB 抗体) regulate preadipocyte adipogenesis possibly through C/EBPb (显示 CEBPB 抗体)-> FoxO1-> C/EBPb (显示 CEBPB 抗体) feedback regulatory loop and FoxO1-C/EBPb (显示 CEBPB 抗体) protein complex.

8. FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.

9. concluded that PI 3 (显示 PI3 抗体)-kinase and Akt (显示 AKT1 抗体) are activated after renal ischemia/reperfusion and that Akt (显示 AKT1 抗体) phosphorylation leads to phosphorylation of FKHR and FKHRL1 (显示 FOXO3 抗体), which may affect epithelial cell fate in acute renal failure.

10. FoxO1a can regulate p27kip nuclear localization

Cow (Bovine) Forkhead Box O1 (FOXO1) interaction partners

1. MicroRNA-183-96-182 cluster regulates bovine granulosa cell function by targeting FOXO1 gene.

2. downregulation of SIRT1 (显示 SIRT1 抗体) and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age

3. FOXO (显示 FOXO3 抗体) is a key regulator of ROS (显示 ROS1 抗体)-induced apoptosis in mammalian cells.

4. Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule (显示 NCAM1 抗体)-1 mRNA.

5. The results demonstrate pathways through which two different mediators, TNF-alpha (显示 TNF 抗体) and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.

Xenopus laevis Forkhead Box O1 (FOXO1) interaction partners

1. FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase (显示 SOD1 抗体) and catalase (显示 CAT 抗体) mRNA and protein levels in this organ.