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Human Cyclin D1 ELISA Kit for Sandwich ELISA - ABIN414406
Bocci, Fioravanti, La Motta, Orlandi, Canu, Di Desidero, Mugnaini, Sartini, Cosconati, Frati, Antonelli, Berti, Miccoli, Da Settimo, Danesi: Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells. in Biochemical pharmacology 2011
Show all 5 Pubmed References
a new function for cyclin D1 in the control of redox metabolism and interactions of cyclin D1-expressing multiple myeloma cells with their bone marrow microenvironment.
these results demonstrated that miR (显示 MLXIP ELISA试剂盒)-146a-5p could suppress the proliferation and cell cycle progression in non-small cell lung cancer cells by inhibiting the expression of CCND1 and CCND2 (显示 CCND2 ELISA试剂盒)
Study confirms previous observation that high cyclin D1 expression is associated to high proliferation and a threefold higher risk of death from breast cancer in ER-positive breast cancer
CCND1 plays these essential roles likely through involvement in DNA replication to minimize DNA damage.
MiR (显示 MLXIP ELISA试剂盒)-374a inactivates the PI3K (显示 PIK3CA ELISA试剂盒)/AKT (显示 AKT1 ELISA试剂盒) axis by inhibiting CCND1, suppressing of colon cancer progression.
Overexpression of cyclin D1 results in dysregulated CDK (显示 CDK4 ELISA试剂盒) activity, rapid cell growth under conditions of restricted mitogenic signaling, bypass of key cellular checkpoints, and ultimately, neoplastic growth. (Review)
a RAGE (显示 AGER ELISA试剂盒)-dependent polyP-mediated crosstalk between mTOR (显示 FRAP1 ELISA试剂盒) and the GSK-3 (显示 GSK3b ELISA试剂盒)/Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling network can modulate important physiological processes in endothelial cells that involve cyclin D1
Results indicate that miR (显示 MLXIP ELISA试剂盒)-134 played a pivotal role on NSCLC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic CCND1.
Patients with tumors with high amplification of CCND1 had an increased risk of recurrence. These findings suggest that CCND1 amplification could be useful for predicting recurrence in invasive breast cancer
Data suggest that subcellular localization of cyclin D1 (Ccnd1) is an interesting guideline to measure cancer outcome.
Cyclin D1 is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 in hematopoiesis.
NMB or NMBR (显示 NMBR ELISA试剂盒) silencing inhibited M-CSF (显示 CSF1R ELISA试剂盒)/c-Fms (显示 CSF1R ELISA试剂盒)-mediated downstream signaling pathways like activation of ERK (显示 EPHB2 ELISA试剂盒) and Akt (显示 AKT1 ELISA试剂盒) and induction of D-type cyclins, cyclin D1 and D2.
Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1 (显示 CTNNB1 ELISA试剂盒)-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.
identify Pax5 (显示 PAX5 ELISA试剂盒) and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.
Data show that expression of the Oct-4 (显示 POU5F1 ELISA试剂盒), Sox2 (显示 SOX2 ELISA试剂盒), Klf4 (显示 KLF4 ELISA试剂盒), and c-Myc (显示 MYC ELISA试剂盒) (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.
study shows that PLCgamma1 (显示 PLCG1 ELISA试剂盒) controls osteoclast numbers via a CSF-1 (显示 CSF1 ELISA试剂盒)-dependent DAG/beta-catenin (显示 CTNNB1 ELISA试剂盒)/cyclinD1 pathway.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (显示 MYC ELISA试剂盒), Cyc (显示 CYCS ELISA试剂盒)-D1 and TERT (显示 TERT ELISA试剂盒), respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment.
Using Ccnd1 knockout mice, the study shows that Ccnd1 expression significantly contributes to tumor incidence in teratoma (显示 DND1 ELISA试剂盒) susceptible mice without being necessary for normal germ cell or testis development.
Ras (G12V)-induced cyclin D1 protein synthesis was markedly suppressed by the knockdown of IL-33 (显示 IL33 ELISA试剂盒).
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
show that the knockdown of smc1a (显示 SMC1A ELISA试剂盒) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels
Reduction of cyclin D1 expression compromises zebrafish eye and head development.
Role in cell cycle control is mediated by meis1 (显示 MEIS1 ELISA试剂盒) regulating cyclin D1 and c-myc (显示 MYC ELISA试剂盒) transcription in the embryonic eye.
Results suggest that the TCF (显示 HNF4A ELISA试剂盒)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
cyclin D1, CDK2 (显示 CDK2 ELISA试剂盒) and CDK4 (显示 CDK4 ELISA试剂盒) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (显示 MAPK3 ELISA试剂盒) kinase) pathway.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
B-cell CLL/lymphoma 1
, B-cell lymphoma 1 protein
, BCL-1 oncogene
, G1/S-specific cyclin-D1
, PRAD1 oncogene
, G1/S-specific cyclin-D1 b
, cyclin D1 b
, parathyroid adenomatosis 1
, G1/S-specific cyclin-D1 a
, cyclin D1 a (PRAD1: parathyroid adenomatosis 1)
, cyclin D1 (PRAD1: parathyroid adenomatosis 1)
, cyclin D1