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Human Polyclonal AKT Primary Antibody for IHC, WB - ABIN361978
Kim, Lee, Kim, Bahk: A Proteomic approach for protein-profiling the oncogenic ras induced transformation (H-, K-, and N-Ras) in NIH/3T3 mouse embryonic fibroblasts. in Proteomics 2008
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Human Polyclonal AKT Primary Antibody for CyTOF, FACS - ABIN4900619
Wang, Yue, Kim, Fu, Khuri, Sun: Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation. in Cancer research 2008
Show all 16 Pubmed References
Human Polyclonal AKT Primary Antibody for IHC, WB - ABIN362584
Bahk, Cho, Kim: A cross-talk between oncogenic Ras and tumor suppressor PTEN through FAK Tyr861 phosphorylation in NIH/3T3 mouse embryonic fibroblasts. in Biochemical and biophysical research communications 2008
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Human Monoclonal AKT Primary Antibody for IHC, IHC (p) - ABIN252685
Luty, Rodeberg, Parness, Vyas: Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates. in Journal of immunology (Baltimore, Md. : 1950) 2007
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Human Monoclonal AKT Primary Antibody for ICS - ABIN1177030
Prinz, Mendler, Masouris, Durner, Oberneder, Noessner: High DGK-α and disabled MAPK pathways cause dysfunction of human tumor-infiltrating CD8+ T cells that is reversible by pharmacologic intervention. in Journal of immunology (Baltimore, Md. : 1950) 2012
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Human Polyclonal AKT Primary Antibody for IP, WB - ABIN223018
Artwohl, Muth, Kosulin, de Martin, Hölzenbein, Rainer, Freudenthaler, Huttary, Schmetterer, Waldhäusl, Baumgartner-Parzer: R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1. in American journal of physiology. Endocrinology and metabolism 2007
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Human Polyclonal AKT Primary Antibody for IF, IHC - ABIN361980
Tremblay, Krebs, Dombrowski, Brehm, Bernroider, Roth, Nowotny, Waldhäusl, Marette, Roden: Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. in Diabetes 2005
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Human Monoclonal AKT Primary Antibody for WB - ABIN4279016
Nair, Shishodia, Ahn, Kunnumakkara, Sethi, Aggarwal: Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion. in Journal of immunology (Baltimore, Md. : 1950) 2006
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Human Monoclonal AKT Primary Antibody for ICS, WB - ABIN967668
Alessi, Andjelkovic, Caudwell, Cron, Morrice, Cohen, Hemmings: Mechanism of activation of protein kinase B by insulin and IGF-1. in The EMBO journal 1997
Show all 5 Pubmed References
Dog (Canine) Monoclonal AKT Primary Antibody for IF, IP - ABIN968218
Cantley, Neel: New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. in Proceedings of the National Academy of Sciences of the United States of America 1999
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Data show that sulfatase 1 (hSulf-1 (显示 SULF1 抗体)) overexpression in melanoma cells can inhibit cell proliferation and induce cell cycle arrest and apoptosis by decreasing the protein kinase B (AKT) phosphorylation and limiting cyclin dependent kinase 4 (CDK4 (显示 CDK4 抗体)) nuclear import.
In summary, we demonstrate that ADAMTS18 (显示 ADAMTS18 抗体) silencing in breast cancer is significantly correlated with promoter CpG methylation. ADAMTS18 (显示 ADAMTS18 抗体) acts as an antagonist of AKT and NF-kappaB (显示 NFKB1 抗体) signaling, further suppressing EMT (显示 ITK 抗体) and metastasis of breast cancer cells.
eIF3d promotes gallbladder cancer (GBC) progression mainly via eIF3d-GRK2 (显示 ADRBK1 抗体)-AKT axis and it may be used as a prognostic factor. The therapeutic targeting of eIF3d-GRK2 (显示 ADRBK1 抗体) axis may be a potential treatment approach for GBC.
Study demonstrates that ROS (显示 ROS1 抗体)-mediated oxidative modification of Akt1 contributes to synaptic dysfunction in Alzheimer's disease, seen as loss of activity-dependent protein translation that is essential for synaptic plasticity and maintenance.
High AKT1 expression is associated with breast cancer.
The results demonstrate that in renal cells, NHE1 (显示 SLC9A1 抗体) is associated with several regulatory proteins including Hsp90 (显示 HSP90 抗体), and that Hsp90 (显示 HSP90 抗体) affects its function possibly through altered phosphorylation of the protein via the AKT kinase.
SMYD3 (显示 SMYD3 抗体)-mediated methylation of AKT1 at lysine 14 is essential for AKT1 activation and that SMYD3 (显示 SMYD3 抗体)-mediated AKT1 methylation appears to be a good target for development of anti-cancer therapy.
Intra-tumour activation of the PTEN/Akt/COX-2 (显示 COX2 抗体) pathway modulates colorectal cancer (CRC (显示 CALR 抗体)) progression and invasive capacity.
BTK (显示 BTK 抗体)-mediated signaling was found to be highly attenuated accompanied by a shift in PI3K (显示 PIK3CA 抗体)/AKT and apoptosis regulation-associated genes/proteins. Cytotoxicity studies using the AKT inhibitor, MK2206+/-ibrutinib, and the Bcl-2 (显示 BCL2 抗体)-specific inhibitor, venetoclax+/-ibrutinib, demonstrated synergistic loss of cell viability
This study for the first time demonstrated that HDAC8 (显示 HDAC8 抗体) activity determines susceptibility to cell cycle arrest induced by Anthrax Lethal Toxin, through regulating the PI3K (显示 PIK3CA 抗体)-PTEN-AKT signaling axis.
both AKT phosphorylation and RAC-dependent membrane ruffling were markedly reduced by depletion of either APPL1 or MYO6. These results place MYO6 and its binding partners at a central nexus in cellular signaling linking actin dynamics at the cell surface and endosomal signaling in the cell cortex.
TXNIP (显示 TXNIP 抗体) is a direct substrate of protein kinase B (AKT) and is responsible for mediating AKT-dependent acute glucose influx after growth factor stimulation.
Influence of 1mM MbetaCD on the fenoterol-driven changes in both contractility and NO level was strongly attenuated by inhibition of Gi-protein (pertussis toxin), Akt (Akt 1/2 kinase inhibitor) or NO-synthase (显示 NOS 抗体) (L-NAME)..Obtained results suggest that slight cholesterol depletion upregulates Gi-protein/Akt/NO-synthase (显示 NOS 抗体) signaling that attenuates the positive inotropic response to b2-adrenergic stimulation
Akt1 conditions the normal circadian rhythm in the vasculature more so than in other peripheral tissues where other AKT isoforms or kinases might be important for daily rhythms.
UVB-irradiated or aged mice skin revealed that mTORC2 (显示 CRTC2 抗体) activity was significantly upregulated which in turn increased Akt activation and Akt-dependent IkappaB kinase alpha (显示 CHUK 抗体) (IKKalpha (显示 CHUK 抗体)) phosphorylation, and The increased mTORC2 (显示 CRTC2 抗体) signaling pathway during skin aging were associated to NF-kappaB (显示 NFKB1 抗体) activation.
this study reveals the function of IL-15 (显示 IL15 抗体) in astrocyte survival via Akt phosphorylation in response to OGD (显示 FGFR1 抗体)-induced damage.
This study demonstrates the neuroprotective effect of TSG (显示 TWSG1 抗体) on APP (显示 APP 抗体) expression, suggesting that TSG (显示 TWSG1 抗体) may be beneficial for AD prevention and treatment.
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
Despite higher endogenous insulin (显示 INS 抗体) concentrations following feeding, arcuate nucleus phosphorylation of Akt (pAkt) levels were significantly lower in the pregnant group compared with the nonpregnant group.
Setdb1 (显示 SETDB1 抗体) regulates PTEN/AKT/FOXO1 (显示 FOXO1 抗体) pathway to inhibit Spermatogonial stem cells apoptosis.
The metabolic defects of cycG (显示 CCNG1 抗体) mutant animals are abrogated by a concomitant loss of Wdb, CycG (显示 CCNG1 抗体) presumably influences Akt1 activity at the PP2A (显示 PPP2R2B 抗体) nexus; Well rounded (Wrd), another B' subunit of PP2A (显示 PPP2R2B 抗体) in Drosophila, binds CycG (显示 CCNG1 抗体) similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG (显示 CCNG1 抗体) mutants.
Our findings demonstrated that lovastatin restored LRRK2-G2019S neurite degeneration by augmenting Akt/NRF2 pathway and inhibiting downstream GSK3b activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2-G2019S parkinsonism.
These findings revise the existing spermiation model in Drosophila and suggest that somatic cells can actively oppose mechanical cell invasion attempts using calibrated F-actin dynamics in situ
subtle manipulation of foxo (显示 FOXO 抗体) through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.
The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones
these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation
AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.
Akt1 governs two critical elements of synapse development, neurotransmitter receptor (显示 GRIN1 抗体) localization, and postsynaptic membrane elaboration
Tsc2 (显示 TSC2 抗体) mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 (显示 TSC2 抗体) mutants, leading to the hypothesis that Tsc2 (显示 TSC2 抗体) and Akt might work via the same genetic pathway to regulate synapse growth.
Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.
This study showed that beta-actin (显示 ACTB 抗体), L32 (显示 RPL32 抗体) ribosomal protein, and ATP5B (显示 ATP5B 抗体) proteins were the most stabily expressed genes in cryopreserved horse semen.
the measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence.
These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (显示 CTNNB1 抗体) accumulation and subsequent ovarian E2 production.
Caveolin-1 (显示 CAV1 抗体) scaffolding domain residue phenylalanine 92 modulates Akt signaling
TG2 (显示 TGM2 抗体) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta, and NF-kappaB (显示 NFKB1 抗体).
The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (显示 NOX1 抗体), reactive oxygen species, and PI3-kinase (显示 PIK3CA 抗体) in stimulated NO release.
PI3K/Akt and p53 (显示 TP53 抗体) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide
Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (显示 NOS3 抗体) activation in endothelial cells
Losartan metabolite stimulates eNOS (显示 NOS3 抗体) phosphorylation and suppresses tumor necrosis factor alpha (显示 TNF 抗体)-induced endothelial cell apoptosis by activating AKT1.
These findings highlight novel and essential roles of PFKFB4 (显示 PFKFB4 抗体) activity in later stages of neural crest (NC) development that are wired into the NC gene regulatory network.
SCF (显示 KITLG 抗体) is a critical regulatory factor for conceptus development and implantation during pregnancy in pigs.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR (显示 FRAP1 抗体)-FOXO1 (显示 FOXO1 抗体) signaling and suppressing the activation of TLR4 (显示 TLR4 抗体) and/or NOD2 (显示 NOD2 抗体) signaling pathways.
Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt signaling pathway may be involved.
In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.
In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.
Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
findings show that megalin (显示 LRP2 抗体) is the sensor that determines whether cells will be protected or injured by albumin (显示 ALB 抗体); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [
protein kinase B (PKB/Akt)was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea
CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.
results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (显示 FNTA 抗体), which further represses the activity of K(+) channel (显示 KCNC4 抗体) AKT1 in Arabidopsis.
Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.
AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.
These findings provide further insights into the signaling network consisting of CBL (显示 CBL 抗体)-CIPK-PP2C interactions in the activation of the AKT1 channel.
Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.
AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.
In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.
CIPK23 directly phosphorylates the K+ transporter AKT1
Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (显示 CA2 抗体)+)-dependent manner, connecting the Ca(2 (显示 CA2 抗体)+) signal to K(+) uptake through activation of a K(+) channel (显示 KCNC4 抗体).
the LIN-28/let-7/AKT/DAF-16 axis is a program that plays an important role in balancing reproduction and somatic maintenance.
this study shows that akt-1 and akt-2 negatively regulate DNA-damage-induced apoptosis in the C. elegans germline and the antiapoptotic activity of akt-1 is independent of its target gene daf-16 but dependent on cep-1/p53 (显示 TP53 抗体).
Modulation of pptr-1 affects insulin (显示 INS 抗体)/IGF-1 (显示 IGF1 抗体) signaling pathway-associated phenotypes including life span, dauer, stress resistance, and fat storage; study shows that PPTR-1 functions by regulating worm AKT-1 phosphorylation at Thr (显示 TRH 抗体) 350.
Exogenous AKT was transcribed, and AKT was overexpressed, inducing the phosphorylation of p70S6K (显示 RPS6KB1 抗体) (Thr389) and 4E-BP1 (显示 EIF4EBP1 抗体) (Thr37/46) in goat fetal fibroblasts.
findings suggested that the expressions of the cardiac CACNA1C (显示 CACNA1C 抗体) were under the CLOCK-BMAL1 (显示 ARNTL 抗体) regulation, probably through the PI3K-Akt signal pathway
Overexpression of human Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
, RAC-alpha serine/threonine-protein kinase
, protein kinase B alpha
, proto-oncogene c-Akt
, rac protein kinase alpha
, AKT1 kinase
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, actin, cytoplasmic 1
, Akt kinase
, dAkt kinase
, protein kinase B
, related to PKA to PKC protein kinases
, related to the A and C kinases
, 5C actin
, actin 5 C
, actin 5C
, actin 5c
, actin A1
, cellular cytoskeletal beta-actin
, gamma non-muscle actin
, beta actin
, RAC protein kinase alpha RAC-PK alpha
, murine thymoma viral (v-akt) oncogene homolog 1
, thymoma viral proto-oncogene 1
, v-akt murine thymoma viral oncogene-like protein 1
, serine/threonine protein kinase
, protein kinase Akt-1
, protein kinase B, alpha
, v-akt murine thymoma viral oncogene homolog 1
, v-akt murine thymoma viral oncogene-like 1