This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008].
Nagpal, Dasgupta, Jadallah, Chae, Ratovitski, Toubaji, Netto, Eagle, Nissan, Sidransky, Trink: "Profiling the expression pattern of GPI transamidase complex subunits in human cancer." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 21, Issue 8, pp. 979-91, (2008) (PubMed).
Ohishi, Nagamune, Maeda, Kinoshita: "Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 13959-67, (2003) (PubMed).
Vainauskas, Maeda, Kurniawan, Kinoshita, Menon: "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex." in: The Journal of biological chemistry, Vol. 277, Issue 34, pp. 30535-42, (2002) (PubMed).
Ohishi, Inoue, Kinoshita: "PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8." in: The EMBO journal, Vol. 20, Issue 15, pp. 4088-98, (2001) (PubMed).
Aliases for PIGK 抗体
phosphatidylinositol glycan anchor biosynthesis class K S homeolog (pigk.S) 抗体 phosphatidylinositol glycan anchor biosynthesis class K (PIGK) 抗体 phosphatidylinositol glycan anchor biosynthesis, class K (Pigk) 抗体 phosphatidylinositol glycan anchor biosynthesis, class K (pigk) 抗体 3000001O05Rik 抗体 GPI8 抗体 zgc:86702 抗体