This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008].
Chen, Hsu, Ma, Tai, Lee: "CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 29, pp. 9574-89, (2014) (PubMed).
Aliases for PIAS1 蛋白
protein inhibitor of activated STAT 1 (PIAS1) 蛋白 protein inhibitor of activated STAT 1 (Pias1) 蛋白 protein inhibitor of activated STAT, 1 (Pias1) 蛋白 protein inhibitor of activated STAT, 1a (pias1a) 蛋白 protein inhibitor of activated STAT 1 L homeolog (pias1.L) 蛋白 2900068C24Rik 蛋白 Ddxbp1 蛋白 DDXBP1 蛋白 ddxbp1 蛋白 GBP 蛋白 gbp 蛋白 GU/RH-II 蛋白 pias 蛋白 pias1-A 蛋白 xPAIS1 蛋白 xPIAS1 蛋白 ZMIZ3 蛋白 zmiz3 蛋白