PI3K p85a/g/b 抗体 (AA 465-469)
Cited in 2+ publications. This 兔 多克隆 anti-PI3K p85a/g/b antibody specifically detects PI3K p85a/g/b in IHC. The antibody is reactive with 人, 小鼠 和 大鼠 samples.
(2 references)
产品编号 ABIN363076
发货至:
中国
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Quick Overview for PI3K p85a/g/b 抗体 (AA 465-469) (ABIN363076)
抗原
PI3K p85a/g/b
(Phosphoinositide 3 Kinase, p85 alpha/gamma/beta (PI3K p85a/g/b))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
应用范围
Immunohistochemistry (IHC)
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抗原表位
- AA 465-469
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特异性
- The antibody detects endogenous level of total PI3K P85 a/g/b protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
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免疫原
- Peptide sequence around AA 465-469, 197-201, 462-466 (L-Y-E-E-Y) derived from Human PI3K P85. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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亚型
- IgG
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应用备注
- Immunohistochemistry: 1:50-1:100
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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: "Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells." in: Lipids in health and disease, Vol. 12, pp. 83, (2013) (PubMed).
: "The "HER2-PI3K/Akt-FASN Axis" regulated malignant phenotype of colorectal cancer cells." in: Lipids, Vol. 47, Issue 4, pp. 403-11, (2012) (PubMed).
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: "Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells." in: Lipids in health and disease, Vol. 12, pp. 83, (2013) (PubMed).
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- PI3K p85a/g/b (Phosphoinositide 3 Kinase, p85 alpha/gamma/beta (PI3K p85a/g/b))
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别名
- PI3K P85 alpha/gamma/beta
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背景
- PI3K binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
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分子量
- 85 kDa
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UniProt
- O00459
抗原
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