This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008].
Kaplan, Ledoux, Kassamali, Gagnon, Post, Koehler, Deimling, Sweezey: "A novel developmentally regulated gene in lung mesenchyme: homology to a tumor-derived trypsin inhibitor." in: The American journal of physiology, Vol. 276, Issue 6 Pt 1, pp. L1027-36, (1999) (PubMed).