PHLPP2 蛋白

(PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.

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7 results

PHLPP2 Protein (AA 1-1323) (His tag)

custom-made PHLPP2 宿主: 人宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Human Recombinant PHLPP2 Protein, UniprotID Q6ZVD8

3 images

产品编号 ABIN7554929

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PHLPP2 Protein (AA 1-1320) (His tag)

custom-made PHLPP2 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Mouse Recombinant Phlpp2 Protein, UniprotID Q8BXA7

3 images

产品编号 ABIN7564455

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PHLPP2 Protein (AA 766-1043) (His tag)

PHLPP2 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

Western Blotting (WB) image for PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) (AA 766-1043) protein (His tag) (ABIN7124383)

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产品编号 ABIN7124383

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PHLPP2 Protein (AA 1-1320) (Strep Tag)

custom-made PHLPP2 宿主: 小鼠宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). WB, ELISA, SDS

产品编号 ABIN3136302

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PHLPP2 Protein (AA 1-1323) (Strep Tag)

custom-made PHLPP2 宿主: 人宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). WB, ELISA, SDS

产品编号 ABIN3094545

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