(Protein Geranylgeranyltransferase Type I, beta Subunit (PGGT1B))
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA\; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010].
Lee, Chang, Trinh, Tu, White, Davies, Bergo, Fong, Lowry, Young: "Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes." in: Human molecular genetics, Vol. 19, Issue 8, pp. 1603-17, (2010) (PubMed).
Iguchi, Katsuno, Niwa, Yamada, Sone, Waza, Adachi, Tanaka, Nagata, Arimura, Watanabe, Kaibuchi, Sobue: "TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases." in: The Journal of biological chemistry, Vol. 284, Issue 33, pp. 22059-66, (2009) (PubMed).
Aliases for PGGT1B 抗体
protein geranylgeranyltransferase type I subunit beta (PGGT1B) 抗体 protein geranylgeranyltransferase type I, beta subunit S homeolog (pggt1b.S) 抗体 protein geranylgeranyltransferase type 1 subunit beta (Pggt1b) 抗体 protein geranylgeranyltransferase type I, beta subunit (Pggt1b) 抗体 2010207C17Rik 抗体 2610100E13 抗体 AI451237 抗体 AI551093 抗体 BGG1 抗体 BGGI 抗体 GGT1 抗体 GGTI 抗体 MGC115505 抗体