zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) (N-Term) Peptide
ZAP70
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN986321
发货至:
中国
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Contact Info
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Quick Overview for zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) (N-Term) Peptide (ABIN986321)
抗原
ZAP70
(zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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序列
- MRKKQIDVAI KVLKQGTEKA DTEEMMREAQ IMHQLDNPYI VRLIGVCQAE
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产品特性
- This is a synthetic peptide designed for use in combination with anti-ZAP70 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
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背景
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This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Alias Symbols: FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
Protein Interaction Partner: CRK,CRK,CRKL,ZAP70,ABL1,ACP1,CARD11,CBL,CBLB,CD247,CD3E,CD5,CD79B,CRK,DBNL,DEF6,DUSP3,FCGR3A,FCRL3,FYN,GAB2,GRB2,IFNAR1,LAT,LAX1,LCK,LCP2,MUC1,NFAM1,PAG1,PLCG1,PRLR,PTK2B,PTPN22,PTPN3,PTPN6,PTPRC,RASA1,SH2B3,SH3BP2,SHB,SHC1,SIT1,SLA,SLA2,SLAMF6,SOS1,TUBA4
Protein Size: 312 -
分子量
- 34 kDa
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基因ID
- 7535
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NCBI登录号
- NM_207519, NP_997402
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UniProt
- P43403
抗原
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