Tumor Protein P63 (TP63) (N-Term) Peptide
TP63
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all p63 (TP63) products
- p63 (TP63) (Tumor Protein P63 (TP63))
- 蛋白结构域
- N-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-TP63 antibody (Catalog #: ARP33998_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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Tumor Protein P63 (TP63) peptide (Ovalbumin)
TP63 适用: 人 宿主: 合成 WB, Imm, SDS
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- p63 (TP63) (Tumor Protein P63 (TP63))
- 背景
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This protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3), split-hand/foot malformation 4 (SHFM4), ankyloblepharon-ectodermal defects-cleft lip/palate, ADULT syndrome (acro-dermato-ungual-lacrimal-tooth), limb-mammary syndrome, Rap-Hodgkin syndrome (RHS), and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
Alias Symbols: B(p51A), B(p51B), EEC3, KET, LMS, OFC8, RHS, SHFM4, TP73L, p51, p63, p73H, p73L, AIS, NBP, p40, TP53L, p53CP, TP53CP
Protein Interaction Partner: FAS,DAXX,EP300,GRB2,HIPK2,HNRNPAB,PPP1R13B,PPP2R5A,TP53,TP63,TP73,WT1,BTRC,GNB2L1,HIPK2,HNRNPAB,SFRS15,UBC,YAP1
Protein Size: 680 - 分子量
- 77 kDa
- 基因ID
- 8626
- NCBI登录号
- NM_003722, NP_003713
- UniProt
- Q9H3D4
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